Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Integrin binding revealed

The difficult task of providing an atomic-level picture of integrin adhesion is beginning to bear fruit with the determination of the crystal structure of an α-chain sub-domain that has primary ligand-binding epitopes.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Lee, J.-O., Rieu, P., Arnaout, M.A. & Liddington, R. Cell 80, in the press.

  2. Graves, B.J. et al. Nature 367, 532–538 (1994).

    Article  CAS  Google Scholar 

  3. Arnaout, M.A., Gupta, S.K., Pierce, M.W. & Tenen, D.G. J. cell Biol. 106, 2153–2158 (1988).

    Article  CAS  Google Scholar 

  4. Michishita, M., Videm, V. & Arnaout, M.A. Cell 72, 857–867 (1993).

    Article  CAS  Google Scholar 

  5. Ueda, T., Rieu, P., Brayer, J. & Arnaout, M.A. Proc. natn. Acad. Sci. U.S.A. 91, 10680–10684 (1994).

    Article  CAS  Google Scholar 

  6. Rieu, P., Ueda, T., Haruta, I., Sharma, C.P. & Arnaout, M.A. J. cell Biol. 127, 2081–2091 (1994).

    Article  CAS  Google Scholar 

  7. Kamata, T., Puzon, W. & Takada, Y. J. biol. Chem. 269, 9659–9663 (1994).

    CAS  PubMed  Google Scholar 

  8. Randi, A.M. & Hogg, N. J. biol. Chem. 269, 12395–12398 (1994).

    CAS  PubMed  Google Scholar 

  9. Zhou, L., Lee, D.H.S., Plescia, J., Lau, C.Y. & Altieri, D.C. J. biol. Chem. 269, 17075–17079 (1994).

    CAS  PubMed  Google Scholar 

  10. Kern, A., Briesewitz, R., Bank, I. & Marcantonio, E.E. J. biol. Chem. 269, 22811–22816 (1994).

    CAS  PubMed  Google Scholar 

  11. Diamond, M.S., Garcia-Aguilar, J., Bickford, J.K., Corbi, A.L. & Springer, T.A. J. cell Biol. 120, 1031–1043 (1993).

    Article  CAS  Google Scholar 

  12. Takada, Y. & Hemler, M.E. J. cell Biol. 109, 397–407 (1989).

    Article  CAS  Google Scholar 

  13. Branden, C. & Tooze, J. Introduction to Protein Structure, 43–57 (Garland Publishing, 1991).

    Google Scholar 

  14. Gailit, J. & Ruoslahti, E. J. biol. Chem. 263, 12927–12932 (1988).

    CAS  PubMed  Google Scholar 

  15. Hynes, R.O. Cell 69, 11–25 (1992).

    Article  CAS  Google Scholar 

  16. Taniguchi-Sidle, A. & Isenman, D.E. J. Immunol. 153, 5285–5302 (1994).

    CAS  PubMed  Google Scholar 

  17. Staunton, D.E., Dustin, M.L., Erickson, H.P. & Springer, T.A. Cell 61, 243–254 (1990).

    Article  CAS  Google Scholar 

  18. Altieri, D.C. J. Immunol. 147, 1891–1898 (1991).

    CAS  PubMed  Google Scholar 

  19. Dransfield, I., Cabañas, C., Craig, A. & Hogg, N., J. cell Biol. 116, 219–226 (1992).

    Article  CAS  Google Scholar 

  20. Bodian, D.L., Bottomley, M., Harlos, K., Jones, E.Y. & Stuart, D.I. Nature 373, in the press (1995).

    Google Scholar 

  21. Nicholls, A. GRASP: Graphical Representation and Analysis of Surface Properties (Columbia University, 1992).

    Google Scholar 

  22. Tamkun, J.W. et al. Cell 46, 271–282 (1986).

    Article  CAS  Google Scholar 

  23. Hynes, R.O. Cell 48, 549–554 (1987).

    Article  CAS  Google Scholar 

  24. Larson, R.S., Corbi, A.L., Berman, L. & Springer, T. J. cell Biol. 108, 703–712 (1989).

    Article  CAS  Google Scholar 

  25. Colombatti, A. & Bonaldo, P. Blood 77, 2305–2315 (1991).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Graves, B. Integrin binding revealed. Nat Struct Mol Biol 2, 181–183 (1995). https://doi.org/10.1038/nsb0395-181

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsb0395-181

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing