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Folding by association

Abstract

Recent studies of folding of multimeric proteins reveal diverse folding scenarios — ranging from 'induced fit' reactions to 'lock and key' mechanisms.

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Figure 1: Structure of the p53tet dimer.

References

  1. Koshland, D. (ed. Kasha, M. & Pullman, B.) 69–84 (Academic Press, New York; 1962).

  2. Levine, A. Cell 88, 323–331 ( 1997).

    Article  CAS  Google Scholar 

  3. Jeffrey, P, Gorina, S. & Pavletich, N. Science 267, 1498– 1502 (1995).

    Article  CAS  Google Scholar 

  4. Mateu, M, del Pino, MS & Fersht, A. Nature Struct. Biol. 6, 190– 198 (1999).

    Google Scholar 

  5. Walburger, C., Johnson, T & Sauer, R. Proc. Natl. Acad. Sci. USA 93, 2629–2634 (1996).

    Article  Google Scholar 

  6. Milla, M.E., Brown, B.M., Waldburger, C. & Sauer, R.T. Biochemistry 34, 13914–13919 (1995).

    Article  CAS  Google Scholar 

  7. Closs, L. & Matthews, C.R. Biochemistry 45 15990–15999 (1998).

    Google Scholar 

  8. Closs, L. & Matthews, C.R. Biochemistry 45, 16000–16010 (1998).

    Google Scholar 

  9. Billing, G. & Mikkelsen, K. Introduction to molecular dynamics and chemical kinetics. (Wiley, New York; 1996).

    Book  Google Scholar 

  10. Gutin, A., Abkevich, V. & Shakhnovich, E. Biochemistry 34, 3066– 3076 (1995).

    Article  CAS  Google Scholar 

  11. Qi, P., Sosnick, T. & Englander, S. Nature Struct. Biol. 5, 882– 884 (1998).

    Article  CAS  Google Scholar 

  12. Jackson, S & Fersht, A. Biochemistry 30, 10428–10435 (1991).

    Article  CAS  Google Scholar 

  13. Schindler, T., Herrler, M., Marahiel, M. & Schmid F. Nature Struct. Biol. 2, 663–673 (1995).

    Article  CAS  Google Scholar 

  14. Choe, S, Matsudaira, P, Osterhout, J, Wagner, G & Shakhnovich, E. Biochemistry 37, 14508–14518 (1998).

    Article  CAS  Google Scholar 

  15. Jackson, S. Folding & Design 3, R81–R91 (1998).

    Article  CAS  Google Scholar 

  16. Shastry, M & Roder, H. Nature Struct. Biol. 5 , 385–392 (1998).

    Article  CAS  Google Scholar 

  17. Khorazanisadeh, S., Peters, I. & Roder, H. Nature Struct. Biol., 89, 193– 205 (1996).

    Article  Google Scholar 

  18. Itzhaki, L,, Otzen, D. & Fersht A. J. Mol. Biol. 254, 260– 288 (1995).

    Article  CAS  Google Scholar 

  19. Abkevich, V, Gutin, A. & Shakhnovich, E. Biochemistry 33, 10026– 10036 (1994).

    Article  CAS  Google Scholar 

  20. Martinez, J, Pissabarro, T. & Serrano, L. Nature Struct. Biol. 5, 721– 729 (1998).

    Article  CAS  Google Scholar 

  21. Shakhnovich, E., Abkevich, V. & Ptitsyn, O. Nature 379, 96– 98 (1996).

    Article  CAS  Google Scholar 

  22. Pande, V, Grosberg, A., Rokshar, D., Tanaka, T. Curr. Opin. Struct. Biol. 8, 68–79 (1998).

    Article  CAS  Google Scholar 

  23. Mirny, L., Abkevich, V., & Shakhnovich, E. Proc. Natl. Acad. Sci. USA 95, 4976–4981 (1998).

    Article  CAS  Google Scholar 

  24. Shakhnovich, E. Folding & Design 3, R108–R111 (1998).

    Article  CAS  Google Scholar 

  25. Mateu, M. & Fersht, A. EMBO J. 17, 2748–2758 (1998).

    Article  CAS  Google Scholar 

  26. Vilegas, V., Martinez, J., Avilez, F. & Serrano, L. J. Mol. Biol. 283, 1027–1036 (1998).

    Article  Google Scholar 

  27. Broglia, R., Tiana, G., Pasquali, S., Roman, R., & Vigezzi, E. Proc. Natl. Acad. Sci. USA 95, 12930–12933 (1998).

    Article  CAS  Google Scholar 

  28. Higgs, P. & Joanny, JF. J. Chem. Phys. 94, 1543–1555 (1991).

    Article  CAS  Google Scholar 

  29. Kantor, Y, Kardar, M. & Li H. Phys. Rev. E 49, 1383–1392 (1994).

    Article  CAS  Google Scholar 

  30. Gutin, AM. & Shakhnovich, E. Phys. Rev. E 50, R3322–R3325 (1994).

    Article  CAS  Google Scholar 

  31. Abkevich, V., Gutin, A., & Shakhnovich, E. Proc. Natl. Acad. Sci. USA 93, 839–844 (1996).

    Article  CAS  Google Scholar 

  32. Netzer, W. & Hartl, FU. Trends Biochem. Sci. 23, 68–73 (1998).

    Article  CAS  Google Scholar 

  33. Munoz, V. & Serrano L. Folding & Design 1, R71–R77 (1996).

    Article  CAS  Google Scholar 

  34. Sharman, G. et al. Folding & Design 3, 313– 320 (1998).

    Article  CAS  Google Scholar 

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Shakhnovich, E. Folding by association. Nat Struct Mol Biol 6, 99–102 (1999). https://doi.org/10.1038/5785

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