The structure of human cathepsin K, a potential target for treatment of osteoporosis, reveals active site differences with homologous cysteine proteinases that should enable the design of cathepsin K selective inhibitors.
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Zhao, B., Janson, C., Amegadzie, B. et al. Crystal structure of human osteoclast cathepsin K complex with E-64. Nat Struct Mol Biol 4, 109–111 (1997). https://doi.org/10.1038/nsb0297-109
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DOI: https://doi.org/10.1038/nsb0297-109
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