Second messenger control of chromatin remodeling

Two recent studies show that some ATP-dependent chromatin remodeling complexes are subject to control by a surprising set of regulators — phosphoinositols. These studies extend earlier observations in mammalian cells and suggest that second messengers are regulators of chromatin remodeling.

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Figure 1: Small molecule control of chromatin remodeling in yeast.
Figure 2: Small molecule control of chromatin remodeling in mammals.

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Correspondence to Gerald R. Crabtree.

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