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A new beginning of the end of translation

The structures of peptide release factors raise new questions about their mechanism of action in protein synthesis.

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Acknowledgements

We thank V. Ramakrishnan, R. Buckingham, J. Frank and U. Rawat for helpful comments on the manuscript. This work was supported by the Swedish Foundation for Strategic Research, the Swedish Research Council, the Wenner-Grenska Samfundet Foundation and the Estonian Science Foundation.

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Correspondence to Måns Ehrenberg or Tanel Tenson.

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Figure 1: The similarities and differences between the crystal structure of tRNA and the structures of proteins involved in termination of translation and subsequent recycling of ribosomes to a new round of initiation.