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Sweet secrets of synthesis

The crystal structure of a `retaining' glycosyltransferase provides the first view of α-glycosidic bond synthesis using activated nucleotide sugars.

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Figure 1: Reaction mechanism for an inverting NDP-sugar glycosyltransferase.
Figure 2: Possible mechanisms for a retaining NDP-sugar glycosyltransferase.
Figure 3: The active center of lgtC is reminiscent of glycogen and maltodextrin phosphorylases.


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Davies, G. Sweet secrets of synthesis. Nat Struct Mol Biol 8, 98–100 (2001).

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