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Intron recognition comes of AGe

Abstract

The molecular basis for the consensus sequence at the 3' ends of introns in higher eukaryotes has now been elucidated. However, this discovery does not explain all aspects of 3' splice site selection.

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Figure 1: a, Consensus sequences found in human introns.
Figure 2: a, Consensus binding sites for the U2AF65 monomer (left) and U2AF65/35 heterodimer (right) determined by iterative in vitro selection.
Figure 3: A longer than usual distance between the PPT and 3' splice site AG in the wild type msl-2 intron allows for inhibition of splicing by the Drosophila Sex-lethal (SXL) protein.

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Moore, M. Intron recognition comes of AGe. Nat Struct Mol Biol 7, 14–16 (2000). https://doi.org/10.1038/71207

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