Abstract
The molecular basis for the consensus sequence at the 3' ends of introns in higher eukaryotes has now been elucidated. However, this discovery does not explain all aspects of 3' splice site selection.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development
Signal Transduction and Targeted Therapy Open Access 13 July 2020
-
A novel LRAT mutation affecting splicing in a family with early onset retinitis pigmentosa
Human Genomics Open Access 04 July 2018
-
Evolutionarily emerged G tracts between the polypyrimidine tract and 3′ AG are splicing silencers enriched in genes involved in cancer
BMC Genomics Open Access 19 December 2014
Access options
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Wu, S., Romfo, C.M., Nilsen, T.W. & Green, M.R. Nature 402, 832–835 ( 1999).
Zorio, D.A.R. & Blumenthal, T. Nature 402, 835–838 (1999).
Merendino, L., Guth, S., Bilbao, D., Martinez, C. & Valcárcel, J. Nature 402, 838– 841 (1999).
Burge, C.B., Tuschl, T. & Sharp, P.A. In The RNA world, second edition. (eds. Gestland, R.F., Cech, T.R. & Atkins, J.F.) 525–560 (Cold Spring Harbor Press, Cold Spring Harbor, New York; 1999).
Senapathy, P., Shapiro, M.B. & Harris, N.L. Methods Enzymol. 183, 252– 278 (1990).
Anderson, K. & Moore, M.J. Science 276, 1712–1716 (1997).
Guth, S., Martinez, C., Gaur, R.K. & Valcárcel, J. Mol Cell Biol 19, 8263–8271 ( 1999).
Krämer, A. Annu. Rev. Biochem. 65, 367–409 (1996).
Cáceres, J.F. & Krainer, A.R. In Eukaryotic mRNA processing. (ed. Krainer, A.R.) 174–212 (Oxford University Press, Oxford; 1997).
Singh, R., Valcárcel, J. & Green, M.R. Science 268, 1173– 1176 (1995).
Reed, R. Genes Dev. 3, 2113–2123 (1989).
Zuo, P. & Maniatis, T. Genes Dev. 10, 1356–1368 (1996).
Zhuang, Y. & Weiner, A.M. Gene 90, 263–269 (1990).
Bennett, M., Michaud, S., Kingston, J. & Reed, R. Genes Dev. 6, 1986–2000 ( 1992).
Anderson, K. & Moore, M.J. RNA 6, 1– 10 (2000).
Rymond, B.C. & Rosbash, M. Nature 317, 735–737 (1985).
Zhou, Z. & Reed, R. EMBO J. 17, 2095–2106 (1998).
Schwer, B. & Gross, C.H. EMBO J 17, 2086–2094 (1998).
Collins, C.A. & Guthrie, C. Genes Dev. 13, 1970–1982 (1999).
Chua, K. & Reed, R. Nature 402, 207–210 (1999).
Chen, S., Anderson, K. & Moore, M.J. Proc. Natl. Acad. USA, in the press (2000).
Gozani, O., Patton, J.G. & Reed, R. EMBO J. 13, 3356– 3367 (1994).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Moore, M. Intron recognition comes of AGe. Nat Struct Mol Biol 7, 14–16 (2000). https://doi.org/10.1038/71207
Issue Date:
DOI: https://doi.org/10.1038/71207
This article is cited by
-
Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development
Signal Transduction and Targeted Therapy (2020)
-
A novel LRAT mutation affecting splicing in a family with early onset retinitis pigmentosa
Human Genomics (2018)
-
A Novel Alzheimer-Associated SNP in Tmp21 Increases Amyloidogenesis
Molecular Neurobiology (2018)
-
The Arabidopsis splicing factors, AtU2AF65, AtU2AF35, and AtSF1 shuttle between nuclei and cytoplasms
Plant Cell Reports (2017)
-
Diverse regulation of 3′ splice site usage
Cellular and Molecular Life Sciences (2015)