A recent study suggests modulation of luteinizing hormone signalling within the hypothalamic–pituitary–gonadal axis and downstream transcriptional effects caused by sustained ibuprofen use. However, this study cannot be used to draw any clinical conclusions regarding effects of ibuprofen on male androgenic or reproductive health. Thus, the andrological effects of its use remain unclear and would benefit from further investigation.
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The authors would like to thank Brian Chase, biostatistician in the Department of Urology, University of Kansas Health System, for his comments on the statistics of the paper under discussion.
The authors declare no competing financial interests.
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Nangia, A., Jensen, D. Ibuprofen and hypogonadism — bench to bedside to misinterpreted hype?. Nat Rev Urol 15, 268–269 (2018). https://doi.org/10.1038/nrurol.2018.26
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