News & Views | Published:

Andrology

Ibuprofen and hypogonadism — bench to bedside to misinterpreted hype?

Nature Reviews Urology volume 15, pages 268269 (2018) | Download Citation

A recent study suggests modulation of luteinizing hormone signalling within the hypothalamic–pituitary–gonadal axis and downstream transcriptional effects caused by sustained ibuprofen use. However, this study cannot be used to draw any clinical conclusions regarding effects of ibuprofen on male androgenic or reproductive health. Thus, the andrological effects of its use remain unclear and would benefit from further investigation.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    et al. Analgesic use — prevalence, biomonitoring and endocrine and reproductive effects. Nat. Rev. Endocrinol. 12, 381–393 (2016).

  2. 2.

    & Pain medications and male reproduction. Adv. Exp. Med. Biol. 1034, 39–57 (2017).

  3. 3.

    et al. Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism. Proc. Natl Acad. Sci. USA 115, E715–E724 (2018).

  4. 4.

    et al. Activation of satellite cells and the regeneration of human skeletal muscle are expedited by ingestion of nonsteroidal anti-inflammatory medication. FASEB J. 30, 2266–2281 (2016).

  5. 5.

    et al. Can serum testosterone be used as a marker of overall health? Rev. Urol. 17, 226–230 (2015).

  6. 6.

    et al. Dose-dependent effects of recombinant human interleukin-6 on the pituitary-testicular axis. J. Interferon Cytokine Res. 19, 1271–1276 (1999).

  7. 7.

    et al. Use of non-prescription analgesics and male reproductive function. Reprod. Toxicol. 74, 70–76 (2017).

  8. 8.

    et al. Endocrine disruption and consequences of chronic exposure to ibuprofen in Japanese medaka (Oryzias latipes) and freshwater cladocerans Daphnia magna and Moina macrocopa. Aquat. Toxicol. 98, 256–264 (2010).

Download references

Acknowledgements

The authors would like to thank Brian Chase, biostatistician in the Department of Urology, University of Kansas Health System, for his comments on the statistics of the paper under discussion.

Author information

Affiliations

  1. Department of Urology, University of Kansas Health System, Kansas City, KS, USA.

    • Ajay K. Nangia
    •  & Derek Jensen

Authors

  1. Search for Ajay K. Nangia in:

  2. Search for Derek Jensen in:

Contributions

A.N. wrote the manuscript. Both authors researched data for the article, took part in discussions of content, and reviewed and edited the manuscript before submission.

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Ajay K. Nangia.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nrurol.2018.26

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing