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Ibuprofen and hypogonadism — bench to bedside to misinterpreted hype?

Nature Reviews Urology volume 15, pages 268269 (2018) | Download Citation

A recent study suggests modulation of luteinizing hormone signalling within the hypothalamic–pituitary–gonadal axis and downstream transcriptional effects caused by sustained ibuprofen use. However, this study cannot be used to draw any clinical conclusions regarding effects of ibuprofen on male androgenic or reproductive health. Thus, the andrological effects of its use remain unclear and would benefit from further investigation.

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The authors would like to thank Brian Chase, biostatistician in the Department of Urology, University of Kansas Health System, for his comments on the statistics of the paper under discussion.

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  1. Department of Urology, University of Kansas Health System, Kansas City, KS, USA.

    • Ajay K. Nangia
    •  & Derek Jensen


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A.N. wrote the manuscript. Both authors researched data for the article, took part in discussions of content, and reviewed and edited the manuscript before submission.

Competing interests

The authors declare no competing financial interests.

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Correspondence to Ajay K. Nangia.

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