Evaluation of Decipher (a 22-gene genomic classifier) shows that this biomarker panel independently predicts metastasis in patients with prostate cancer and PSA ≥ 0.1 ng/ml after prostatectomy. In these men, the 5-year metastasis rate was significantly higher in those with genomic high risk according to Decipher than in those with genomic low or intermediate risk (P < 0.001). In multivariate analysis, Decipher high risk was the only independent predictor of metastases (HR 5.61, 95% CI 1.48–22.7; P = 0.01)
References
Spratt, D. E. et al. Performance of a prostate cancer genomic classifier in predicting metastasis in men with prostate-specific antigen persistence postprostatectomy. Eur. Urol. http://dx.doi.org/10.1016/j.eururo.2017.11.024 (2017)
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Thoma, C. Predicting risk of metastasis after prostatectomy. Nat Rev Urol 15, 137 (2018). https://doi.org/10.1038/nrurol.2017.228
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DOI: https://doi.org/10.1038/nrurol.2017.228
