A study in men with prostate cancer who underwent early salvage radiotherapy evaluated whether the effect of androgen deprivation therapy (ADT) on metastasis depends on disease features. ADT given during early salvage radiotherapy owing to biochemical recurrence after prostatectomy was only beneficial in men with aggressive disease features (stage pT3b/4 and grade group ≥4, or pT3b/4 and PSA ≥ 0.4 ng/ml).
References
Gandaglia, G. et al. Use of concomitant androgen deprivation therapy in patients treated with early salvage radiotherapy for biochemical recurrence after radical prostatectomy: long-term results from a large, multi-institutional series. Eur. Urol. http://dx.doi.org/10.1016/j.eururo.2017.11.020 (2017)
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Thoma, C. Utility of ADT during early salvage radiotherapy. Nat Rev Urol 15, 137 (2018). https://doi.org/10.1038/nrurol.2017.226
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DOI: https://doi.org/10.1038/nrurol.2017.226