A study in men with prostate cancer who underwent early salvage radiotherapy evaluated whether the effect of androgen deprivation therapy (ADT) on metastasis depends on disease features. ADT given during early salvage radiotherapy owing to biochemical recurrence after prostatectomy was only beneficial in men with aggressive disease features (stage pT3b/4 and grade group ≥4, or pT3b/4 and PSA ≥ 0.4 ng/ml).