Testicular cancer in 2017

Sequencing advances understanding

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Our biological understanding of TGCTs has been improved using sequencing, and molecular profiles associated with the genomic evolution and development of cisplatin resistance have been identified. The genomics of variants underpinning TGCT predisposition is being delineated. Studies of circulating microRNAs have demonstrated their potential for noninvasive diagnosis and disease monitoring.

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Acknowledgements

M.J.M. acknowledges grant funding from The St Baldrick's Foundation and the Isaac Newton Trust. M.J.M is grateful for support from the Max Williamson Fund and from Christiane and Alan Hodson, in memory of their daughter Olivia. C.T. acknowledges support from the Movember foundation.

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Correspondence to Matthew J. Murray or Clare Turnbull.

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The authors declare no competing financial interests.

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Murray, M., Turnbull, C. Sequencing advances understanding. Nat Rev Urol 15, 79–80 (2018) doi:10.1038/nrurol.2017.209

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