Predicting stone episodes using cystine capacity

Cystine capacity is an assay for assessing urinary cystine saturation and risk of a stone episode in patients with cystinuria. Lowering the threshold for this test improves its sensitivity, potentially enabling relaxation of follow-up regimens for patients at lowest risk of stone episodes and dose modification of medications for those at highest risk.

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Figure 1: Distribution of cystine capacity measurements in a recent study of 48 patients with cystinuria.


  1. 1

    Friedlander, J. I. et al. Do urinary cystine parameters predict clinical stone activity? J. Urol. (2017).

  2. 2

    Coe, F. L., Clark, C., Parks, J. H. & Asplin, J. R. Solid phase assay of urine cystine supersaturation in the presence of cystine binding drugs. J. Urol. 166, 688–693 (2001).

    CAS  Article  Google Scholar 

  3. 3

    Dolin, D. et al. Effect of cystine-binding thiol drugs on urinary cystine capacity in patients with cystinuria. J. Endourol. 19, 429–432 (2005).

    Article  Google Scholar 

  4. 4

    Wong, K. et al. Can the presence of crystalluria predict stone formation in patients with cystinuria? J. Endourol. 30, 609–614 (2016).

    Article  Google Scholar 

  5. 5

    Pardy, C. et al. Urinary lysine is a better predictor of cystine stone formation than urinary cystine. Eur. Urol. Suppl. 10, 227 (2011).

    Article  Google Scholar 

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Correspondence to Matthew Bultitude or Kay Thomas.

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The authors declare no competing financial interests.

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Bultitude, M., Thomas, K. Predicting stone episodes using cystine capacity. Nat Rev Urol 15, 8–9 (2018).

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