Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Stones

Predicting stone episodes using cystine capacity

Nature Reviews Urology volume 15, pages 8–9 (2018)Cite this article

Subjects

Cystine capacity is an assay for assessing urinary cystine saturation and risk of a stone episode in patients with cystinuria. Lowering the threshold for this test improves its sensitivity, potentially enabling relaxation of follow-up regimens for patients at lowest risk of stone episodes and dose modification of medications for those at highest risk.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Distribution of cystine capacity measurements in a recent study of 48 patients with cystinuria.

References

  1. Friedlander, J. I. et al. Do urinary cystine parameters predict clinical stone activity? J. Urol. http://dx.doi.org/10.1016/j.juro.2017.09.034 (2017).

  2. Coe, F. L., Clark, C., Parks, J. H. & Asplin, J. R. Solid phase assay of urine cystine supersaturation in the presence of cystine binding drugs. J. Urol. 166, 688–693 (2001).

    Article  CAS  Google Scholar 

  3. Dolin, D. et al. Effect of cystine-binding thiol drugs on urinary cystine capacity in patients with cystinuria. J. Endourol. 19, 429–432 (2005).

    Article  Google Scholar 

  4. Wong, K. et al. Can the presence of crystalluria predict stone formation in patients with cystinuria? J. Endourol. 30, 609–614 (2016).

    Article  Google Scholar 

  5. Pardy, C. et al. Urinary lysine is a better predictor of cystine stone formation than urinary cystine. Eur. Urol. Suppl. 10, 227 (2011).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Matthew Bultitude and Kay Thomas are at the Stone Unit, Guy's and St Thomas' NHS Foundation Trust, 1st Floor Southwark Wing, Guy's Hospital, Great Maze Pond, London SE1 9RT, UK.,

    Matthew Bultitude & Kay Thomas

Authors
  1. Matthew Bultitude
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kay Thomas
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Matthew Bultitude or Kay Thomas.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

PowerPoint slides

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bultitude, M., Thomas, K. Predicting stone episodes using cystine capacity. Nat Rev Urol 15, 8–9 (2018). https://doi.org/10.1038/nrurol.2017.189

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrurol.2017.189

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research