Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Paediatrics

Integrating genomics to dig deeper into Wilms tumour biology

Nature Reviews Urology volume 14, pages 703–704 (2017)Cite this article

Subjects

A new study provides a comprehensive catalogue of the genetic changes in Wilms tumour. Understanding the interplay between genetic and epigenetic aberrations during tumorigenesis and clonal evolution is fundamental to enabling prediction of who is at risk and which tumours will relapse when so many are curable.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Dome, J. S. et al. Children's Oncology Group's 2013 blueprint for research: renal tumors. Pediatr. Blood Cancer 60, 994–1000 (2013).

    Article  Google Scholar 

  2. Brok, J., Treger, T. D., Gooskens, S. L., van den Heuvel-Eibrink, M. M. & Pritchard-Jones, K. Biology and treatment of renal tumours in childhood. Eur. J. Cancer 68, 179–195 (2016).

    Article  CAS  Google Scholar 

  3. Torrezan, G. T. et al. Recurrent somatic mutation in DROSHA induces microRNA profile changes in Wilms tumour. Nat. Commun. 5, 4039 (2014).

    Article  CAS  Google Scholar 

  4. Walz, A. L. et al. Recurrent DGCR8, DROSHA, and SIX homeodomain mutations in favorable histology Wilms tumors. Cancer Cell 27, 286–297 (2015).

    Article  CAS  Google Scholar 

  5. Wegert, J. et al. Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors. Cancer Cell 27, 298–311 (2015).

    Article  CAS  Google Scholar 

  6. Gadd, S. et al. A Children's Oncology Group and TARGET initiative exploring the genetic landscape of Wilms tumor. Nat. Genet. 49, 1487–1494 (2017).

    Article  CAS  Google Scholar 

  7. Cresswell, G. D. et al. Intra-tumor genetic heterogeneity in Wilms tumor: clonal evolution and clinical implications. EBioMedicine 9, 120–129 (2016).

    Article  Google Scholar 

  8. Scott, R. H. et al. Stratification of Wilms tumor by genetic and epigenetic analysis. Oncotarget 3, 327–335 (2012).

    Article  Google Scholar 

  9. Charles, A. K., Brown, K. W. & Berry, P. J. Microdissecting the genetic events in nephrogenic rests and Wilms' tumor development. Am. J. Pathol. 153, 991–1000 (1998).

    Article  CAS  Google Scholar 

  10. Scott, R. H. et al. Constitutional 11p15 abnormalities, including heritable imprinting center mutations, cause nonsyndromic Wilms tumor. Nat. Genet. 40, 1329–1334 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. William Mifsud is at the Department of Histopathology, Great Ormond Street Hospital for Children, NHS Foundation Trust, Great Ormond Street, London WC1N 3JH, UK and UCL Great Ormond Street Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK.,

    William Mifsud

  2. Kathy Pritchard-Jones is at the Department of Oncology, Great Ormond Street Hospital for Children, NHS Foundation Trust, Great Ormond Street, London WC1N 3JH, UK and the UCL Great Ormond Street Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK.,

    Kathy Pritchard-Jones

Authors
  1. William Mifsud
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kathy Pritchard-Jones
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kathy Pritchard-Jones.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mifsud, W., Pritchard-Jones, K. Integrating genomics to dig deeper into Wilms tumour biology. Nat Rev Urol 14, 703–704 (2017). https://doi.org/10.1038/nrurol.2017.178

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrurol.2017.178

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer