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Male factor infertility

Declining sperm counts — the never-ending story

Nature Reviews Urology volume 14, pages 645646 (2017) | Download Citation

A recent systematic review on worldwide declining trends in sperm counts has fuelled alarming reports in national and international news media. However, methodological issues exist with data gathering and analysis precluding any conclusion and no solid data exist to indicate increasing frequency of couple infertility during past decades.

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References

  1. 1.

    et al. Temporal trends in sperm count: a systematic review and meta-regression analysis. Hum. Reprod. Update. (2017).

  2. 2.

    & Male fertility potential in terms of semen quality: a review of the past, a study of the present. Fertil. Steril. 31, 103–116 (1979).

  3. 3.

    , , & Evidence for decreasing quality of semen during past 50 years. BMJ 305, 609–613 (1992).

  4. 4.

    Declining worldwide sperm counts: disproving a myth. Urol. Clin. North Am. 35, 137–146 (2008).

  5. 5.

    Myth and methodology in the evaluation of human sperm output. Int. J. Androl. 23 (Suppl. 2), 50–53 (2000).

  6. 6.

    et al. Human semen quality in the new millennium: a prospective cross-sectional population-based study of 4867 men. BMJ Open 2, e000990 (2012).

  7. 7.

    , , , & Ever growing demand for in vitro fertilization despite stable biological fertility — a European paradox. Eur. J. Obstet. Gynecol. Reprod. Biol. 214, 204–208 (2017).

  8. 8.

    et al. Relation between semen quality and fertility: a population-based study of 430 first-pregnancy planners. Lancet 352, 1172–1177 (1998).

  9. 9.

    et al. The epidemiologic evidence linking prenatal and postnatal exposure to endocrine disrupting chemicals with male reproductive disorders: a systematic review and meta-analysis. Hum. Reprod. Update 23, 104–125 (2016).

  10. 10.

    & Does relaxed reproductive selection explain the decline in male reproductive health? A new hypothesis. Epidemiology 13, 113–114 (2002).

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Author information

Affiliations

  1. Jens Peter Bonde is at the Department of Occupational and Environmental Medicine, Bispebjerg-Frederiksberg University Hospital, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark.

    • Jens Peter Bonde
  2. Egbert te Velde is at the Department of Public Health, Erasmus University Medical Center, POBox 2040, 3000 GA, Rotterdam, The Netherlands.

    • Egbert te Velde

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Jens Peter Bonde.

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DOI

https://doi.org/10.1038/nrurol.2017.153

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