In clinical studies, mirabegron has been shown to cause a small increase in heart rate with a slight increase in QTc interval, as indicated on electrocardiograms. The mechanisms of these effects are unclear. The findings of a recent study might provide some new clues, although, the relevance of these new observations to the treatment of patients with overactive bladder syndrome have yet to be established.
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K-E.A. declares that he is a consultant and/or on the advisory board for Allergan, Astellas and Ferring.
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Andersson, KE. Cardiovascular effects of mirabegron. Nat Rev Urol 14, 587–588 (2017). https://doi.org/10.1038/nrurol.2017.113
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DOI: https://doi.org/10.1038/nrurol.2017.113
