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  • Year in Review
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Prostate cancer in 2016

Improved outcomes and precision medicine come within reach

2016 was an important year for prostate cancer research. New clinical data highlight the need for personalized treatment across clinical disease states and have changed clinical practice for men with metastatic disease. Molecular studies have characterized tumour heterogeneity and informed biomarker development for advanced disease and research into mechanisms of treatment resistance.

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References

  1. Hamdy, F. C. et al. 10-year outcomes after monitoring, surgery, or radiotherapy for localized prostate cancer. N. Engl. J. Med. 375, 1415–1424 (2016).

    Article  PubMed  Google Scholar 

  2. James, N. D. et al. Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial. Lancet 387, 1163–1177 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Sweeney, C. L. et al. Chemohormonal therapy in metastatic hormone-sensitive prostate cancer. N. Engl. J. Med. 373, 737–746 (2016).

    Article  Google Scholar 

  4. Sweeney, C. et al. Long term efficacy and QOL data of chemohormonal therapy (C-HT) in low and high volume hormone naïve metastatic prostate cancer (PrCa): E3805 CHAARTED trial [abstract 720PD]. Ann. Oncol. 27 (Suppl. 6), vi243–vi265 (2016).

    Google Scholar 

  5. Vale, C. L. et al. Addition of docetaxel or bisphosphonates to standard of care in men with localised or metastatic, hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data. Lancet Oncol. 17, 243–256 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Robinson, D. et al. Integrative clinical genomics of advanced prostate cancer. Cell 161, 1215–1228 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Pritchard, C. C. et al. Inherited DNA-repair gene mutations in men with metastatic prostate cancer. N. Engl. J. Med. 375, 443–453 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Wyatt, A. W. et al. Genomic alterations in cell-free DNA and enzalutamide resistance in castration-resistant prostate cancer. JAMA Oncol. 2, 1598–1606 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Beltran, H. et al. Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer. Nat. Med. 22, 298–305 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Kumar, A. et al. Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer. Nat. Med. 22, 369–378 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Both authors researched data for the article, made substantial contributions to discussion of its content, wrote the article and reviewed/edited the manuscript before submission.

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Correspondence to Cora N. Sternberg or Himisha Beltran.

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The authors declare no competing financial interests.

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Sternberg, C., Beltran, H. Improved outcomes and precision medicine come within reach. Nat Rev Urol 14, 71–72 (2017). https://doi.org/10.1038/nrurol.2016.270

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