Urinary incontinence

Making sense of the urinary microbiota in clinical urology

Some urologists might be surprised that the urinary tract is not sterile, and bacteria might have important roles in a number of urological conditions such as urge incontinence. This paradigm shift, which has been further illustrated by data from a recent study, has implications for how urologists diagnose disease and treat patients.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Anatomy of the vagus nerve.

References

  1. 1

    Thomas-White, K. J. et al. Evaluation of the urinary microbiota of women with uncomplicated stress urinary incontinence. Am. J. Obstet. Gynecol. http://dx.doi.org/10.1016/j.ajog.2016.07.049 (2016).

  2. 2

    Urbaniak, C. et al. The microbiota of breast tissue and its association with cancer. Appl. Environ. Microbiol. 82, 5039–5048 (2016).

    CAS  Article  Google Scholar 

  3. 3

    Branton, W. G. et al. Brain microbial populations in HIV/AIDS: α-proteobacteria predominate independent of host immune status. PLoS ONE 8, e54673 (2013).

    CAS  Article  Google Scholar 

  4. 4

    Goneau, L. W. et al. Selective target inactivation rather than global metabolic dormancy causes antibiotic tolerance in uropathogens. Antimicrob. Agents Chemother. 58, 2089–2097 (2014).

    Article  Google Scholar 

  5. 5

    Montiel-Castro, A. J. González-Cervantes, R. M., Bravo-Ruiseco, G. & Pacheco-López, G. The microbiota-gut-brain axis: neurobehavioral correlates, health and sociality. Front. Integr. Neurosci. 7, 70 (2013).

    Article  Google Scholar 

  6. 6

    Gloor, G. B. & Reid, G. Compositional analysis: a valid approach to analyze microbiome high-throughput sequencing data. Can. J. Microbiol. 62, 692–703 (2016).

    CAS  Article  Google Scholar 

  7. 7

    McMillan, A. et al. A multi-platform metabolomics approach identifies highly specific biomarkers of bacterial diversity in the vagina of pregnant and non-pregnant women. Sci. Rep. 5, 14174 (2015).

    CAS  Article  Google Scholar 

  8. 8

    Blaser, M. J. Antibiotic use and its consequences for the normal microbiome. Science 352, 544–545 (2016).

    CAS  Article  Google Scholar 

  9. 9

    Kranjčec, B. Papeš, D. & Altarac, S. d-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J. Urol. 32, 79–84 (2014).

    Article  Google Scholar 

  10. 10

    Fischer, M. et al. Faecal microbiota transplantation plus selected use of vancomycin for severe-complicated Clostridium difficile infection: description of a protocol with high success rate. Aliment. Pharmacol. Ther. 42, 470–476 (2015).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Gregor Reid.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

PowerPoint slides

Glossary

Microbiota

The term microbiota describes all microorganisms present in a given niche. In many instances, studies only refer to bacteria in the microbiota, but fungi and viruses, for example, can also be included in this term.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Reid, G., Burton, J. Making sense of the urinary microbiota in clinical urology. Nat Rev Urol 13, 567–568 (2016). https://doi.org/10.1038/nrurol.2016.182

Download citation

Further reading