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Bladder cancer

ASCO endorses EAU muscle-invasive bladder cancer guidelines

A multidisciplinary expert panel from the American Society of Clinical Oncology has endorsed the updated European Association of Urology guidelines for the management of muscle-invasive bladder cancer, with one exception. The panel also provides additional clarification of several recommendations.

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References

  1. Milowsky, M. I. et al. Guideline on muscle-invasive and metastatic bladder cancer (European Association of Urology Guideline): American Society of Clinical Oncology Clinical Practice Guideline Endorsement. J. Clin. Oncol. 34, 1945–1952 (2016).

    Article  Google Scholar 

  2. Nayan, M. et al. The initiation of a multidisciplinary bladder cancer clinic and the uptake of neoadjuvant chemotherapy: a time-series analysis. Can. Urol. Assoc. J. 10, 25–30 (2016).

    Article  Google Scholar 

  3. International collaboration of trialists. Neoadjuvant cisplatin, methotrexate, and vinblastine chemotherapy for muscle-invasive bladder cancer: a randomised controlled trial. Lancet 354, 533–540 (1999).

  4. Grossman, H. B. et al. Neoadjuvant chemotherapy plus cystectomy compared with cystectomy alone for locally advanced bladder cancer. N. Engl. J. Med. 349, 859–866 (2003).

    Article  CAS  Google Scholar 

  5. Bochner, B. H. et al. Comparing open radical cystectomy and robot-assisted laparoscopic radical cystectomy: a randomized clinical trial. Eur. Urol. 67, 1042–1050 (2015).

    Article  Google Scholar 

  6. Smith, N. D. et al. The RAZOR (randomized open versus robotic cystectomy) trial: study design and trial update. BJU Int. 115, 198–205 (2015).

    Article  Google Scholar 

  7. Gray, P. J. et al. Use of potentially curative therapies for muscle-invasive bladder cancer in the United States: results from the National Cancer Data Base. Eur. Urol. 63, 823–829 (2013).

    Article  Google Scholar 

  8. Choi, W. et al. Identification of distinct basal and luminal subtypes of muscle-invasive bladder cancer with different sensitivities to frontline chemotherapy. Cancer Cell 25, 152–165 (2014).

    Article  CAS  Google Scholar 

  9. Van Allen, E. M. et al. Somatic ERCC2 mutations correlate with cisplatin sensitivity in muscle-invasive urothelial carcinoma. Cancer Discov. 4, 1140–1153 (2014).

    Article  CAS  Google Scholar 

  10. Chou, R. et al. Treatment of Nonmetastatic Muscle-Invasive Bladder Cancer (Agency for Healthcare Research and Quality (US), 2015).

    Google Scholar 

Download references

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Correspondence to Seth P. Lerner.

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Competing interests

S.L. has worked with BioCancell, Vaxxion Therapeutics, UroGen Pharma, Telesta Therapeutics, Sitka Biopharma, Neucleixx, Taris Biomedical, Ferring Pharmaceuticals and the Bladder Cancer Journal. He has received grants from ENDO Intenational, FKD Therapies, Viventia Bio, Roche, Genentech and Genome DX.

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Lerner, S. ASCO endorses EAU muscle-invasive bladder cancer guidelines. Nat Rev Urol 13, 440–441 (2016). https://doi.org/10.1038/nrurol.2016.114

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