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  • Review Article
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The inconspicuous penis in children

Key Points

  • An inconspicuous penis can result in considerable concern for both parents and children

  • 9% of patients presenting for initial circumcision have evidence of an inconspicuous penis

  • Micropenis is defined as stretched penile length that is at least 2.5 SD below the mean for the patient's age, without any other abnormalities, such as hypospadias

  • 'True micropenis', caused by deficient secretion and action of testosterone, should be distinguished from 'concealed micropenis'

  • Medical and surgical treatments for inconspicuous penis disorders aim to restore normal penis size, standing micturition and enable future sexual activity

  • Surgical correction of concealed penis is currently the gold-standard treatment

Abstract

The term 'inconspicuous penis' refers to a group of anatomical abnormalities in which the penis looks smaller than is expected. Micropenis can be defined as 'true micropenis'—which results from a defect in the hypothalamic–pituitary–gonadal axis—and 'micropenis secondary to congenital anatomical anomalies of the surrounding and overlying structures'—also known as 'concealed penis'. The different forms of concealed penis include webbed penis, congenital megaprepuce and partially hidden penis caused by prepubic adiposity. This disorder can also have iatrogenic causes resulting from adhesions that are secondary to circumcision—this type of concealed penis is known as 'trapped penis'. However, in both groups, micropenis is defined as a stretched penile length that is at least 2.5 SD below the mean for the patient's age, but without any other penile defects. Patients with true micropenis can be managed with testosterone, which has demonstrated good penile elongation results in the long term. Surgery also has a pivotal role in reconstruction for elongating the penis and for correction of anatomical abnormalities in concealed penis.

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Figure 1
Figure 2: Surgical correction of buried penis with congenital megaprepuce.
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References

  1. Bergeson, P. S., Hopkin, R. J., Bailey, R. B., McGill, L. C. & Piattt, J. P. The inconspicuous penis. Pediatrics 92, 794–799 (1993).

    CAS  PubMed  Google Scholar 

  2. Maizels, M., Zaontz, M., Donovan, J., Bushnik, P. N. & Firlit, C. F. Surgical correction of the buried penis: description of a classification system and a technique to correct the disorder. J. Urol. 136, 268–271 (1986).

    Article  CAS  PubMed  Google Scholar 

  3. Williams, C. P., Richardson, B. G. & Bukowski, T. P. Importance of identifying the inconspicuous penis: prevention of circumcision complications. Urology 56, 140–143 (2000).

    Article  CAS  PubMed  Google Scholar 

  4. Cytryn, L., Cytryn, E. & Rieger, R. E. Psychological implications of cryptorchidism. J. Am. Acad. Child. Psychiatry 6, 131–165 (1967).

    Article  CAS  PubMed  Google Scholar 

  5. Wiygul, J. & Palmer, L. S. Micropenis. Scientific World Journal 11, 1462–1469 (2011).

    Article  PubMed  Google Scholar 

  6. Johnson, P. & Maxwell, D. Fetal penile length. Ultrasound Obstet. Gynecol. 15, 308–310 (2000).

    Article  CAS  PubMed  Google Scholar 

  7. Zalel, Y., Pinhas-Hamiel, O., Lipitz, S., Mashiach, S. & Achiron, R. The development of the fetal penis—an in utero sonographic evaluation. Ultrasound Obstet. Gynecol. 17, 129–131 (2001).

    Article  CAS  PubMed  Google Scholar 

  8. Aaronson, I. A. Micropenis: medical and surgical implications. J. Urol. 152, 4–14 (1994).

    Article  CAS  PubMed  Google Scholar 

  9. Tuladhar, R., Davis, P. G. & Batch, J. Establishment of a normal range of penile length in preterm infants. J. Paediatr. Child Health 34, 471–473 (1998).

    Article  CAS  PubMed  Google Scholar 

  10. Schonfeld, W. A. & Beebe, G. W. Normal growth and variation in the male genitalia from birth to maturity. J. Urol. 48, 759–777 (1942).

    Article  Google Scholar 

  11. Tuladhar, R., Davis, P. G. & Batch, J. Establishment of a normal range of penile length in preterm infants. J. Paediatr. Child Health 34, 471–473 (1998).

    Article  CAS  PubMed  Google Scholar 

  12. Feldman, K.W. & Smith. D. W. Fetal phallic growth and penile standards for newborn male infants. J. Pediatr. 86, 395–398 (1975).

    Article  CAS  PubMed  Google Scholar 

  13. Camurdan, A. D. et al. Current stretched penile length cross-sectional study of 1040 healthy Turkish children aged 0 to 5 years. Urology 70, 572–575 (2007).

    Article  PubMed  Google Scholar 

  14. Kulkarni, M. L. & Rajendran, N. K. Normal values for penile standards in newborns. Indian Pediatr. 39, 183–186 (1989).

    Google Scholar 

  15. Callen, N. et al. Sexual quality of life after hormonal and surgical treatment, including phalloplasty, in men with micropenis: a review. J. Sex. Med. 10, 2890–2903 (2013).

    Article  Google Scholar 

  16. Kayes, O. et al. Therapeutic strategies for patients with micropenis or penile dysmorphic disorder. Nat. Rev. Urol. 9, 499–507 (2012).

    Article  PubMed  Google Scholar 

  17. Kousta, E., Papathanasiou, A. & Skordis, N. Sex determination and disorders of sex development according to the revised nomenclature and classification in 46, XX individuals. Hormones (Athens) 9, 218–231 (2010).

    Article  Google Scholar 

  18. Hughes, I. A. in Pediatric Endocrinology. 3rd edn Ch. 16 (ed. Sperling, M. A.) 662–685 (Elsevier, 2008).

    Book  Google Scholar 

  19. Achermann, J. C. & Hughes, I. A. in Williams Textbook of Endocrinology. 12th edn Ch. 23 (eds Melmed, S. et al.) 868–934 (Elsevier 2011).

    Book  Google Scholar 

  20. Grumbach, M. M. A window of opportunity: the diagnosis of gonadotropin deficiency in the male infant. J. Clin. Endocrinol. Metab. 90, 3122–3127 (2005).

    Article  CAS  PubMed  Google Scholar 

  21. Hughes, I. A. et al. Consensus Statement on management of intersex disorders. J. Pediatr. Urol. 2, 148–162 (2006).

    Article  CAS  PubMed  Google Scholar 

  22. Quigley, C. A. Editorial: The postnatal gonadotropin and sex steroid surge—Insights from the androgen insensitivity syndrome. J. Clin. Endocrinol. Metab. 87, 24–28 (2002).

    CAS  PubMed  Google Scholar 

  23. Witchel, S. F. & Lee, P. A. in Pediatric Endocrinology. 3rd edn Ch. 4 (ed. Sperling, M. A.) 127–164 (Elsevier, 2008).

    Book  Google Scholar 

  24. Lee, P. A. et al. Micropenis. I. Criteria, etiologies and classification. Johns Hopkins Med. J. 146, 156–163 (1980).

    CAS  PubMed  Google Scholar 

  25. Ahmed, S. F. et al. The role of a clinical score in the assessment of ambiguous genitalia. BJU Int. 85, 120–124 (2000).

    Article  CAS  PubMed  Google Scholar 

  26. Bertelloni, S. et al. Early diagnosis of 5alpha-reductase deficiency in newborns. Sex. Dev. 1, 147–151 (2007).

    Article  CAS  PubMed  Google Scholar 

  27. Walter, K. N. et al. Difficulties in diagnosis and treatment of 5 α-reductase type 2 deficiency in a newborn with 46, XY DSD. Horm. Res. Paediatr. 74, 67–71 (2010).

    Article  CAS  PubMed  Google Scholar 

  28. Tar, A. et al. Hypertelorism and hypospadias associated with a de novo apparently balanced translocation between 8q22.3–23 and 20p13. Am. J. Med. Genet. 68, 231–235 (1997).

    Article  CAS  PubMed  Google Scholar 

  29. Imperato-McGinley, J. et al. Androgens and the evolution of male-gender identity among male pseudohermaphrodites with 5alpha-reductase deficiency. N. Engl. J. Med. 300, 1233–1237 (1979).

    Article  CAS  PubMed  Google Scholar 

  30. Ludwig, G. Micropenis and apparent micropenis—a diagnostic and therapeutic challenge. Andrologia 31 (Suppl. 1), 27 (1999).

    PubMed  Google Scholar 

  31. Elder, J. in Campbell-Walsh Urology. 9th edn Ch. 129 (ed. Cambell, M. et al.) 3751–3754 (Elsevier, 2007).

    Google Scholar 

  32. Bin-Abbas, B., Conte, F. A., Grumbach, M. M. & Kaplan, S. L. Congenital hypogonadotropic hypogonadism and micropenis: effect of testosterone treatment on adult penile size. Why sex reversal is not indicated. J. Pediatr. 134, 579–583 (1999).

    Article  CAS  PubMed  Google Scholar 

  33. Burstein, S., Grumbach, M. M. & Kaplan, S. L. Early determination of androgen-responsiveness is important in the management of microphallus. Lancet 2, 983–986 (1979).

    Article  CAS  PubMed  Google Scholar 

  34. Nerli, R. B., Guntaka, A. K., Patne, P. B. & Hiremath, M. B. Penile growth in response to hormone treatment in children with micropenis. Indian J. Urol. 29, 288–291 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  35. Choi, S. K., Han, S. W., Kim, D. H. & de Lignieres, B. Transdermal dihydrotestosterone therapy and its effects on patients with microphallus. J. Urol. 150, 657–660 (1993).

    Article  CAS  PubMed  Google Scholar 

  36. Ben-Galim, E., Hillman, R. E. & Weldon, V. V. Topically applied testosterone and phallic growth. Its effects in male children with hypopituitarism and microphallus. Am. J. Dis. Child. 134, 296–298 (1980).

    Article  CAS  PubMed  Google Scholar 

  37. Hatipoĝlu, N. & Kurtoĝlu, S. Micropenis: etiology, diagnosis and treatment approaches. J. Clin. Res. Pediatr. Endocrinol. 5, 217–223 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  38. Main, K. M., Schmidt, I. M., Toppari, J. & Skakkebaek, N. E. Early postnatal treatment of hypogonadotropic hypogonadism with recombinant human FSH and LH. Eur. J. Endocrinol. 146, 75–79 (2002).

    Article  CAS  PubMed  Google Scholar 

  39. Bougnères, P. et al. Effects of an early postnatal treatment of hypogonadotropic hypogonadism with a continuous subcutaneous infusion of recombinant follicle-stimulating hormone and luteinizing hormone. J. Clin. Endocrinol. Metab. 93, 2202–2205 (2008).

    Article  CAS  PubMed  Google Scholar 

  40. Cortes, D., Müller, J. & Skakkebaek, N. E. Proliferation of Sertoli cells during development of the human testis assessed by stereological methods. Int. J. Androl. 10, 589–596 (1987).

    Article  CAS  PubMed  Google Scholar 

  41. Sutherland, R. S. et al. The effect of prepubertal androgen exposure on adult penile length. J. Urol. 156, 783–787 (1996).

    Article  CAS  PubMed  Google Scholar 

  42. Kogan, S. J. & Williams, D. I. The micropenis syndrome: clinical observations and expectations for growth. J. Urol. 118, 311–313 (1977).

    Article  CAS  PubMed  Google Scholar 

  43. Jones, H. W. Jr, Park, I. J. & Rock, J. A. Technique of surgical sex reassignment for micropenis and allied conditions. Am. J. Obstet. Gynecol. 132, 870–877 (1978).

    Article  PubMed  Google Scholar 

  44. Hinman, F. Jr . Microphallus: characteristics and choice of treatment from a study of 20 cases. J. Urol. 107, 499–505 (1972).

    Article  PubMed  Google Scholar 

  45. Song, R., Gao, Y., Song, Y., Yu, Y. & Song, Y. The forearm flap. Clin. Plast. Surg. 9, 21–26 (1982).

    CAS  PubMed  Google Scholar 

  46. Kabalin, N., Rosen, J. & Perkash, I. Penile advancement and lengthening in spinal cord injury patients with extracted phallus who have failed penile prosthesis placement alone. J. Urol. 144, 316–318 (1990).

    Article  CAS  PubMed  Google Scholar 

  47. Mokhless, I. A., Abdeldaeim, H. M., Rahman, A., Zahran, M. & Safwat, A. Penile advancement and lengthening for the management of post-circumcision traumatic short penis in adolescents. Urology 76, 1483–1487 (2010).

    Article  PubMed  Google Scholar 

  48. Li, C.-Y. et al. Penile suspensory ligament division for penile augmentation: indications and results. Eur. Urol. 49, 729–733 (2006).

    Article  PubMed  Google Scholar 

  49. Babaei, A., Safarinejad, M. R., Farrokhi, F. & Iran-Pour, E. Penile reconstruction: evaluation of the most accepted techniques. Urol. J. 7, 71–78 (2010).

    PubMed  Google Scholar 

  50. Lumen, N., Monstrey, S., Ceulemans, P., van Laecke, E. & Hoebeke, P. Reconstructive surgery for severe penile inadequacy: phalloplasty with a free radial forearm flap or a pedicled anterolateral thigh flap. Adv. Urol. http://dx.doi.org/10.1155/2008/704343.

  51. Monstrey, S. et al. Penile reconstruction: is the radial forearm flap really the standard technique? Plast. Reconstr. Surg. 124, 510–518 (2009).

    Article  CAS  PubMed  Google Scholar 

  52. Leriche, A. et al. Long-term outcome of forearm flee-flap phalloplasty in the treatment of transsexualism. BJU Int. 101, 1297–1300 (2008).

    Article  PubMed  Google Scholar 

  53. Fang, R. H., Kao, Y. S., Ma, S. & Lin, J. T. Phalloplasty in female-to-male transsexuals using free radial osteocutaneous flap: a series of 22 cases. Br. J. Plast. Surg. 52, 217–222 (1999).

    Article  CAS  PubMed  Google Scholar 

  54. Yang, B., Liu, X. R., Hong, Q. Q., Qiu, R. S. & Ji, C. Y. A comparative study on two kinds of surgical procedures of penile corpora cavernosa augmentation. J. Plast. Reconstr. Aesthet. Surg. 62, 357–364 (2009).

    Article  PubMed  Google Scholar 

  55. Reilly, J. M. & Woodhouse, C. R. Small penis and the male sexual role. J. Urol. 142, 569–571 (1989).

    Article  CAS  PubMed  Google Scholar 

  56. Lee, P. A. & Houk, C. P. Outcome studies among men with micropenis. J. Pediatr. Endocrinol. Metab. 17, 1043–1053 (2004).

    PubMed  Google Scholar 

  57. Wisniewski, A. B. & Migeon, C. J. Long-term perspectives for 46, XY patients affected by complete androgen insensitivity syndrome or congenital micropenis. Semin. Reprod. Med. 20, 297–304 (2002).

    Article  PubMed  Google Scholar 

  58. Radhakrishnan, J., Razzaq, A. & Manickam, K. Concealed penis. Pediatr. Surg. Int. 18, 668–672 (2002).

    PubMed  Google Scholar 

  59. Chu, C. C., Chen, Y. H., Diau, G. Y., Loh, I. W. & Chen, K. C. Preputial flaps to correct buried penis. Pediatr. Surg. Int. 23, 1119–1121 (2007).

    Article  PubMed  Google Scholar 

  60. Crawford, B. S. Buried penis. Br. J. Plast. Surg. 30, 96–99 (1977).

    Article  CAS  PubMed  Google Scholar 

  61. Redman, J. F. Buried penis: a congenital syndrome of a short penile shaft and a paucity of penile shaft skin. J. Urol. 173, 1714–1717 (2005).

    Article  PubMed  Google Scholar 

  62. Wollin, M., Duffy, P. G., Malone, P. S. & Ransley, P. G. Buried penis. A novel approach. Br. J. Urol. 65, 97–100 (1990).

    Article  CAS  PubMed  Google Scholar 

  63. Joseph, V. T. A new approach to the surgical correction of buried penis. J. Pediatr. Surg. 30, 727–729 (1995).

    Article  CAS  PubMed  Google Scholar 

  64. Cromie, W. J., Ritchey, M. L., Smith, R. C. & Zagaja, G. P. Anatomical alignment for the correction of buried penis. J. Urol. 160, 1482–1484 (1998).

    Article  CAS  PubMed  Google Scholar 

  65. Casale, A. J., Beck, S. D., Cain, M. P., Adams, M. C. & Rink, R. C. Concealed penis in childhood: a spectrum of etiology and treatment. J. Urol. 162, 1165–1168 (1999).

    Article  CAS  PubMed  Google Scholar 

  66. Alter, G. J. & Ehrlich, R. M. A new technique for correction of the hidden penis in children and adults. J. Urol. 161, 455–459 (1999).

    Article  CAS  PubMed  Google Scholar 

  67. Donahoe, P. K. & Keating, M. A. Preputial unfurling to correct the buried penis. J. Pediatr. Surg. 21, 1055–1057 (1986).

    Article  CAS  PubMed  Google Scholar 

  68. Boemers, T. M. L. & De Jong, T. P. V. M. The surgical correction of buried penis: a new technique. J. Urol. 154, 550–552 (1995).

    Article  CAS  PubMed  Google Scholar 

  69. Shapiro, S. R. Surgical treatment of the “buried” penis. Urology 30, 554–559 (1987).

    Article  CAS  PubMed  Google Scholar 

  70. Shenoy, M. U., Srinivasan, J., Sully, L. & Rance, C. H. Buried penis: surgical correction using liposuction and realignment of skin. BJU Int. 86, 527–530 (2000).

    Article  CAS  PubMed  Google Scholar 

  71. Liu, X., He, D. W., Hua, Y., Zhang, D. Y. & Wei, G. H. Congenital completely buried penis in boys: anatomical basis and surgical technique. BJU Int. 112, 271–275 (2013).

    Article  PubMed  Google Scholar 

  72. Perger, L., Hanley, R. S. & Feins, N. R. Penoplasty for buried penis in infants and children: report of 100 cases. Pediatr. Surg. Int. 25, 175–180 (2009).

    Article  PubMed  Google Scholar 

  73. O'Brien, A., Shapiro, A. M. & Frank, J. D. Phimosis or congenital megaprepuce. BJU Int. 73, 719–720 (1994).

    Article  CAS  Google Scholar 

  74. Alter, G. J., Horton, C. E. & Horton, C. E. Jr . Buried penis as a contraindication for circumcision. J. Am. Coll. Surg. 178, 487–490 (1994).

    CAS  PubMed  Google Scholar 

  75. Rod, J., Desmonts, A., Petit, T. & Ravasse, P. Congenital megaprepuce: a 12-year experience (52 cases) of this specific form of buried penis. J. Pediatr. Urol. 9, 784–788 (2013).

    Article  PubMed  Google Scholar 

  76. Brisson, P., Patel, H., Chan, M. & Feins, N. Penoplasty for buried penis in children: report of 50 cases. J. Pediatr. Surg. 36, 421–425 (2001).

    Article  CAS  PubMed  Google Scholar 

  77. Philip, I. & Nicholas, J. L. Congenital giant preputial sac: case reports. J. Pediatr. Surg. 34, 507–508 (1999).

    Article  CAS  PubMed  Google Scholar 

  78. Shenoy, M. U. & Rance, C. H. Surgical correction of congenital megaprepuce. Pediatr. Surg. Int. 15, 593–594 (1999).

    Article  CAS  PubMed  Google Scholar 

  79. Bisotti, P. Su un caso di “virga palmata”. Rass. Int. Clin. Terap. 33, 452–453 (1953).

    CAS  Google Scholar 

  80. Glanz, S. Adult congenital penile deformity. Plast. Reconstr. Surg. 41, 579–580 (1968).

    Article  CAS  PubMed  Google Scholar 

  81. Srinivasan, A. K., Plamer, L. S. & Plamer, J. S. Inconspicuous penis. ScientificWorldJournal 11, 2559–2564 (2011).

    Article  PubMed  PubMed Central  Google Scholar 

  82. Perlmutter, A. D. & Chamberlain, J. W. Webbed penis without chordee. J. Urol. 107, 320–321 (1972).

    Article  CAS  PubMed  Google Scholar 

  83. Masih, B. K. & Brosman, S. A. Webbed penis. J. Urol. 111, 690–692 (1974).

    Article  CAS  PubMed  Google Scholar 

  84. Shepard, G. H., Wilson, C. S. & Sallade, R. L. Webbed penis. Plast. Reconstr. Surg. 66, 453–454 (1980).

    Article  CAS  PubMed  Google Scholar 

  85. Redman, J. F. Technique for the correction of penoscrotal fusion. J. Urol. 133, 432–433 (1985).

    Article  CAS  PubMed  Google Scholar 

  86. Wilson, C. S. & Sallade. R. L. Webbed penis. Plast. Reconstr. Surg. 66, 453–454 (1980).

    Article  PubMed  Google Scholar 

  87. Puri, P. Webbed penis without chordee. J. Pediatr. Surg. 11, 125. (1976).

    Article  CAS  PubMed  Google Scholar 

  88. Dilley, A. V. & Currie, B. G. Webbed penis. Pediatr. Surg. Int. 15, 447–448 (1999).

    Article  CAS  PubMed  Google Scholar 

  89. Montasser, E. & El Gohary, M. A. Webbed penis: a new classification. J. Indian Assoc. Pediatr. Surg. 15, 50–52 (2010).

    Article  Google Scholar 

  90. Williams, C. P., Richardson, B. G. & Bukowski, T. P. Importance of identifying the inconspicuous penis: prevention of circumcision complications. Urology 56, 140–142, (2000).

    Article  CAS  PubMed  Google Scholar 

  91. Blalock, H. J., Vemulakonda, V., Ritchey, M. L. & Ribbeck, M. Outpatient management of phimosis following newborn circumcision. J. Urol. 169, 2332–2334 (2003).

    Article  PubMed  Google Scholar 

  92. Erogĝlu, E., Bastian, O. W., Ozkan, H. C., Yorukalp, O. E. & Goksel, A. K. Buried penis after newborn circumcision. J. Urol. 181, 1841–1843 (2009).

    Article  Google Scholar 

  93. Bekerecioglu, M., Inaloz, H. S., Tercan, M. & Isik, D. Keloid formation on an inconspicuous penis. J. Dermatol. 32, 835–838 (2005).

    Article  PubMed  Google Scholar 

  94. Lipszyc, E., Pfister, C., Liard, A. & Mitrofanoff, P. Surgical treatment of buried penis. Eur. J. Pediatr. Surg. 7, 292–295 (1997).

    Article  CAS  PubMed  Google Scholar 

  95. Palmer, J. S., Elder, J. S. & Palmer, L. S. The use of betamethasone to manage the trapped penis following neonatal circumcision. J. Urol. 174, 1577–1578 (2005).

    Article  CAS  PubMed  Google Scholar 

  96. Radhakrishnan, J. & Reyes, H. M. Penoplasty for buried penis secondary to “radical” circumcision. J. Pediatr. Surg. 19, 629–631 (1984).

    Article  CAS  PubMed  Google Scholar 

  97. Levitt, S. B., Smith, R. B. & Ship, A. G. Iatrogenic microphallus secondary to circumcision. Urology 8, 472–474 (1976).

    Article  CAS  PubMed  Google Scholar 

  98. Gillet, M. D. et al. Split-thickness skin graft for the management of concealed penis. J. Urol. 173, 579–582 (2005).

    Article  Google Scholar 

  99. Borsellino, A., Spagnoli, A., Vallasciani, S., Martini, L. & Ferro, F. Surgical approach to concealed penis: technical refinements and outcome. Urology 69, 1195–1198 (2007).

    Article  CAS  PubMed  Google Scholar 

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P.C. and R.O. researched data for the article. M.C.and M.G. made a substantial contribution todiscussion of content. All authors contributed to writing the article. M.C. reviewed and edited thearticle before submission.

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Cimador, M., Catalano, P., Ortolano, R. et al. The inconspicuous penis in children. Nat Rev Urol 12, 205–215 (2015). https://doi.org/10.1038/nrurol.2015.49

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