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Prostate cancer

Intrapatient heterogeneity in prostate cancer

Nature Reviews Urology volume 12, pages 430–431 (2015)Cite this article

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A newly published study used whole-genome sequencing of multiple prostate tumour foci from several patients with intermediate-risk prostate cancer to track evolutionary patterns and delineate the marked intrapatient molecular heterogeneity of this disease. Their findings have potential implications for the development of clinical prognostic and predictive biomarkers.

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Figure 1: Monoclonal and polyclonal models of metastasis from a multifocal primary prostate cancer.

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Authors and Affiliations

  1. Department of Medicine, Weill Cornell Medical College, 525 East 68th Street, Box 403, New York, 10065, NY, USA

    Himisha Beltran

  2. Centre for Integrative Biology, University of Trento, Via Sommarive 9, Povo, 38123, Trento, Italy

    Francesca Demichelis

Authors
  1. Himisha Beltran
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  2. Francesca Demichelis
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Correspondence to Himisha Beltran.

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The authors declare no competing financial interests.

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Beltran, H., Demichelis, F. Intrapatient heterogeneity in prostate cancer. Nat Rev Urol 12, 430–431 (2015). https://doi.org/10.1038/nrurol.2015.182

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