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Kidney cancer

Single nucleotide polymorphisms in mRCC—is their time up?

Nature Reviews Urology volume 12, pages 424–426 (2015)Cite this article

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A large validation study on the effect of single nucleotide polymorphisms on outcome and adverse events in sunitinib-treated patients with metastatic renal cell carcinoma (mRCC) only confirmed that ABCB1 and CYP3A5 variants are associated with progression-free survival and dose reductions, respectively. Does this mean 'game over' for polymorphism research in mRCC?

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Authors and Affiliations

  1. Department of General Medical Oncology and Laboratory for Experimental Oncology, University Hospitals Leuven, KU Leuven, Herestraat 49, Leuven, B-3000, Belgium

    Benoit Beuselinck

  2. Inserm, UMR-1162, Génomique fonctionnelle des tumeurs solides, Institut Universitaire d'Hématologie (IUH), Rue Juliette Dodu 27, Paris, F-75010, France

    Jessica Zucman-Rossi

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  1. Benoit Beuselinck
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  2. Jessica Zucman-Rossi
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Correspondence to Benoit Beuselinck.

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Competing interests

B.B. is an investigator of the EudraCT: 2011-006085-40/MetaSun trial supported by Pfizer and has received honoraria for educational activities from Amgen and GlaxoSmithKline. J.Z.-R. has received honoraria from Astellas, Bayer, Lilly and Pfizer.

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Beuselinck, B., Zucman-Rossi, J. Single nucleotide polymorphisms in mRCC—is their time up?. Nat Rev Urol 12, 424–426 (2015). https://doi.org/10.1038/nrurol.2015.149

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