Over the past few years the management of patients with metastatic renal cell carcinoma has changed substantially. Although the development of targeted therapies has improved the prognosis of many patients with renal cell carcinoma, a large subset of patients who might benefit from targeted therapies do not receive such treatments.
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References
Smaldone, M. C. et al. Temporal trends and factors associated with receipt of systemic therapy among patients undergoing cytoreductive nephrectomy: an analysis of the national cancer database. J. Urol. http://dx.doi.org/10.1016/j.juro.2014.10.095.
Mickish, J. G. H. et al. Radical nephrectomy plus interferon-α-based immunotherapy compared with interferon α alone in metastatic renal-cell carcinoma: a randomised trial. Lancet 358, 966–970 (2001).
Flanigan R. C. et al. Cytoreduction nephrectomy in metastatic renal cancer: the results of Southwest Oncology Group trial 8949. Proc. Am. Soc. Clin. Oncol. 19, 2a (2000).
Tsao, C. K. et al. Trends in the use of cytoreductive nephrectomy in the United States. Clin. Genitourin. Cancer 10, 159–163 (2012).
Choueiri, T. K. et al. The impact of cytoreductive nephrectomy on survival of patients with metastatic renal cell carcinoma receiving vascular endothelial growth factor targeted therapy. J. Urol. 185, 60–66 (2011).
US National Library of Medicine. ClinicalTrials.gov [online], (2014).
US National Library of Medicine. ClinicalTrials.gov [online], (2012).
Small, A. C. et al. Prevalence and characteristics of patients with metastatic cancer who receive no anticancer therapy. Cancer 118, 5947–5954 (2012).
Hudes, G. et al. Temsirolimus, interferon α, or both for advanced renal-cell carcinoma. N. Engl. J. Med. 356, 2271–2281 (2007).
Heng, D. Y. C. et al. Outcomes of patients with metastatic renal cell carcinoma that do not meet eligibility criteria for clinical trials. Ann. Oncol. 25, 149–154 (2014).
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Mehrazin, R., Galsky, M. Systemic therapy—differentiating the achievable from the achieved. Nat Rev Urol 12, 128–129 (2015). https://doi.org/10.1038/nrurol.2014.358
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DOI: https://doi.org/10.1038/nrurol.2014.358