Bladder preservation for patients with muscle-invasive bladder cancer has the potential to offer a quality-of-life advantage, but owing to the lack of randomized trials oncological equivalence to surgery has not been demonstrated. A new article provides a comprehensive overview of the current status of this procedure, but raises timely and important questions.
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References
Ploussard, G. et al. Critical analysis of bladder sparing with trimodal therapy in muscle-invasive bladder cancer: a systematic review. Eur. Urol. http://dx.doi.org/10.1016/j.eururo.2014.02.038.
Nix, J. et al. Prospective randomized controlled trial of robotic versus open radical cystectomy for bladder cancer: perioperative and pathologic results. Eur. Urol. 57, 196–201 (2010).
Caffo, O., Fellin, G., Graffer, U. & Luciani, L. Assessment of quality of life after cystectomy or conservative therapy for patients with infiltrating bladder carcinoma. A survey by a self-administered questionnaire. Cancer 78, 1089–1097 (1996).
Moon, K., Stukenborg, G. J., Keim, J. & Theodorescu, D. Cancer incidence after localized therapy for prostate cancer. Cancer 107, 991–998 (2006).
Lauss, M., Ringnér, M. & Höglund, M. Prediction of stage, grade, and survival in bladder cancer using genome-wide expression data: a validation study. Clin. Cancer Res. 16, 4421–4433 (2010).
Smith, S. C. et al. A 20-gene model for molecular nodal staging of bladder cancer: development and prospective assessment. Lancet Oncol. 12, 137–143 (2011).
Smith, S. C., Baras, A. S., Lee, J. K. & Theodorescu, D. The COXEN principle: translating signatures of in vitro chemosensitivity into tools for clinical outcome prediction and drug discovery in cancer. Cancer Res. 70, 1753–1758 (2010).
Williams, P. D. et al. Cyclophilin B expression is associated with in vitro radioresistance and clinical outcome after radiotherapy. Neoplasia 13, 1122–1131 (2011).
Dyrskjøt, L. et al. Gene expression in the urinary bladder: a common carcinoma in situ gene expression signature exists disregarding histopathological classification. Cancer Res. 64, 4040–4048 (2004).
Dancik, G. M., Owens, C. R., Iczkowski, K. A. & Theodorescu, D. A cell of origin gene signature indicates human bladder cancer has distinct cellular progenitors. Stem Cells 32, 974–982 (2014).
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Hussain, M., Theodorescu, D. Bladder preservation—learning what we don't know. Nat Rev Urol 11, 310–312 (2014). https://doi.org/10.1038/nrurol.2014.102
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DOI: https://doi.org/10.1038/nrurol.2014.102
