BPH

New mouse model available for study

    New research has found that spontaneously hypertensive rats treated with testosterone simultaneously display erectile dysfunction, enlarged prostates and lower urinary tract symptoms—three common problems in ageing men. The discovery should help scientists study the adverse sexual effects of treatments for BPH and lower urinary tract disorders, which has hitherto been difficult without an animal model that exhibits all three conditions.

    ORIGINAL RESEARCH PAPER

    1. 1

      Oudot, A. et al. A new experimental rat model of erectile dysfunction and lower urinary tract symptoms associated with benign prostatic hyperplasia: the testosterone-supplemented spontaneously hypertensive rat. BJU Int. doi:10.1111/j.1464-410X.2012.11085.x

    Download references

    Rights and permissions

    Reprints and Permissions

    About this article

    Cite this article

    New mouse model available for study. Nat Rev Urol 9, 240 (2012). https://doi.org/10.1038/nrurol.2012.76

    Download citation

    Search

    Nature Briefing

    Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

    Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing