In a study published in The Lancet, long-term androgen suppression (AS) combined with radiotherapy, compared with AS alone, improved outcomes in patients with locally advanced but nonmetastatic prostate cancer. The combined therapy significantly reduced prostate-cancer-specific deaths at 10 years from 23.9% to 11.9% (P <0.001), and improved overall survival.
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References
Widmark, A. et al. Endocrine treatment, with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial. Lancet 373, 301–308 (2009).
Granfors, T., Modig, H., Damber, J. E. & Tomic, R. Long-term follow-up of a randomized study of locally advanced prostate cancer treated with combined orchiectomy and external radiotherapy versus radiotherapy alone. J. Urol. 176, 544–547 (2006).
Bill-Axelson, A. et al. Radical prostatectomy versus watchful waiting in localized prostate cancer: the Scandinavian prostate cancer group-4 randomized trial. J. Natl Cancer Inst. 100, 1144–1154 (2008).
Bolla, M. et al. Ten year results of long term adjuvant androgen deprivation with goserelin in patients with locally advanced prostate cancer: a phase III EORTC study [Abstract]. Int. J. Radiat. Oncol. Biol. Phys. 72, S30–S31 (2008).
Horwitz, E. M. et al. Ten-year follow-up of radiation therapy oncology protocol 92–02: a phase III trial of the duration of elective androgen deprivation in locally advanced prostate cancer. J. Clin. Oncol. 26, 2497–2504 (2008).
Thompson, I. M. et al. Adjuvant radiotherapy for pathologically advanced prostate cancer: a randomized clinical trial. JAMA 296, 2329–2335 (2006).
Thompson, I. M. et al. Adjuvant radiotherapy for pathological T3N0M0 prostate cancer significantly reduces risk of metastases and improves survival: long-term follow-up of a randomized clinical trial. J. Urol. 181, 956–962 (2009).
Bolla, M. et al. Postoperative radiotherapy after radical prostatectomy: a randomised controlled trial (EORTC trial 22911). Lancet 366, 572–578 (2005).
Kuban, D. A. et al. Long-term results of the M. D. Anderson randomized dose-escalation trial for prostate cancer. Int. J. Radiat. Oncol. Biol. Phys. 70, 67–74 (2008).
Mason, M. et al. Defining the need for local therapy in locally advanced prostate cancer: an appraisal of the MRC PR07 study. Clin. Oncol. (R. Coll. Radiol.) 17, 217–218 (2005).
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Thanks to Brian J. Goldsmith, M.D., for his editorial assistance.
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Rosenthal, S. Local control and radiotherapy matter in prostate cancer. Nat Rev Urol 6, 250–251 (2009). https://doi.org/10.1038/nrurol.2009.56
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DOI: https://doi.org/10.1038/nrurol.2009.56
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