New evidence strengthens the hypothesis that exposure to trauma and the associated physiological responses contribute to the development of autoimmune diseases, including systemic lupus erythematosus.
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References
Roberts, A. L. et al. Association of trauma and posttraumatic stress disorder with incident systemic lupus erythematosus in a longitudinal cohort of women. Arthritis Rheumatol. 69, 2162–2169 (2017).
O'Donovan, A. et al. Elevated risk for autoimmune disorders in Iraq and Afghanistan veterans with posttraumatic stress disorder. Biol. Psychiatry 77, 365–374 (2015).
Selye, H. A syndrome produced by diverse nocuous agents. Nature 138, 32 (1936).
Cain, D. W. & Cidlowski, J. A. Immune regulation by glucocorticoids. Nat. Rev. Immunol. 17, 233–247 (2017).
Sternberg, E. M., Chrousos, G. P., Wilder, R. L. & Gold, P. W. The stress response and the regulation of inflammatory disease. Ann. Intern. Med. 117, 854–866 (1992).
Crofford, L. J. The hypothalamic–pituitary–adrenal axis in the pathogenesis of rheumatic diseases. Endocrinol. Metab. Clin. North Am. 31, 1–13 (2002).
Gutierrez, M. A., Garcia, M. E., Rodriguez, J. A., Rivero, S. & Jacobelli, S. Hypothalamic–pituitary–adrenal axis function and prolactin secretion in systemic lupus erythematosus. Lupus 7, 404–408 (1998).
Golier, J. A., Schmeidler, J., Legge, J. & Yehuda, R. Twenty-four hour plasma cortisol and adreno-corticotropic hormone in Gulf War veterans: relationships to posttraumatic stress disorder and health symptoms. Biol. Psychiatry 62, 1175–1178 (2007).
Pascual, V., Farkas, L. & Banchereau, J. Systemic lupus erythematosus: all roads lead to type I interferons. Curr. Opin. Immunol. 18, 676–682 (2006).
Guiducci, C. et al. TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus. Nature 465, 937–941 (2010).
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Morand, E. Stress and the onset of SLE. Nat Rev Rheumatol 14, 127–128 (2018). https://doi.org/10.1038/nrrheum.2018.2
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DOI: https://doi.org/10.1038/nrrheum.2018.2
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