New evidence strengthens the hypothesis that exposure to trauma and the associated physiological responses contribute to the development of autoimmune diseases, including systemic lupus erythematosus.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Roberts, A. L. et al. Association of trauma and posttraumatic stress disorder with incident systemic lupus erythematosus in a longitudinal cohort of women. Arthritis Rheumatol. 69, 2162–2169 (2017).
O'Donovan, A. et al. Elevated risk for autoimmune disorders in Iraq and Afghanistan veterans with posttraumatic stress disorder. Biol. Psychiatry 77, 365–374 (2015).
Selye, H. A syndrome produced by diverse nocuous agents. Nature 138, 32 (1936).
Cain, D. W. & Cidlowski, J. A. Immune regulation by glucocorticoids. Nat. Rev. Immunol. 17, 233–247 (2017).
Sternberg, E. M., Chrousos, G. P., Wilder, R. L. & Gold, P. W. The stress response and the regulation of inflammatory disease. Ann. Intern. Med. 117, 854–866 (1992).
Crofford, L. J. The hypothalamic–pituitary–adrenal axis in the pathogenesis of rheumatic diseases. Endocrinol. Metab. Clin. North Am. 31, 1–13 (2002).
Gutierrez, M. A., Garcia, M. E., Rodriguez, J. A., Rivero, S. & Jacobelli, S. Hypothalamic–pituitary–adrenal axis function and prolactin secretion in systemic lupus erythematosus. Lupus 7, 404–408 (1998).
Golier, J. A., Schmeidler, J., Legge, J. & Yehuda, R. Twenty-four hour plasma cortisol and adreno-corticotropic hormone in Gulf War veterans: relationships to posttraumatic stress disorder and health symptoms. Biol. Psychiatry 62, 1175–1178 (2007).
Pascual, V., Farkas, L. & Banchereau, J. Systemic lupus erythematosus: all roads lead to type I interferons. Curr. Opin. Immunol. 18, 676–682 (2006).
Guiducci, C. et al. TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus. Nature 465, 937–941 (2010).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Morand, E. Stress and the onset of SLE. Nat Rev Rheumatol 14, 127–128 (2018). https://doi.org/10.1038/nrrheum.2018.2
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrrheum.2018.2
This article is cited by
-
Beyond Neuropsychiatric Manifestations of Systemic Lupus Erythematosus: Focus on Post-traumatic Stress Disorder and Alexithymia
Current Rheumatology Reports (2021)
-
Anxiety and Mood Disorders in Systemic Lupus Erythematosus: Current Insights and Future Directions
Current Rheumatology Reports (2018)
