Blood T follicular regulatory (TFR) cells and T follicular helper (TFH) cells could serve as biomarkers of ectopic lymphoid activity in primary Sjögren syndrome (pSS). In 16 patients with pSS, activated PD1+ICOS+ TFH cells in blood were associated with disease activity, whereas the ratio of TFR cells to TFH cells was indicative of ectopic lymphoid neogenesis in minor salivary glands. The ratio of TFR cells to TFH cells in blood also discriminated between patients with pSS and healthy donors.
References
Fonseca, V. R. et al. Blood T follicular regulatory cells/T follicular helper cells ratio marks ectopic lymphoid structure formation and PD-1+ICOS+ T follicular helper cells indicate disease activity in primary Sjögren's syndrome. Arthritis Rheumatol. https://doi.org/10.1002/art.40424 (2018)
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Onuora, S. T cells in blood mark Sjögren syndrome activity. Nat Rev Rheumatol 14, 122 (2018). https://doi.org/10.1038/nrrheum.2018.19
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DOI: https://doi.org/10.1038/nrrheum.2018.19
