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Osteoarthritis

Inflammation and fibrosis in adipose tissue of osteoarthritic joints

Nature Reviews Rheumatology volume 13, pages 325–326 (2017)Cite this article

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The infrapatellar fat pad and other adipose tissues in close proximity to the joint have been linked with osteoarthritis (OA), but the nature of this relationship is unclear. Two new studies elucidate the features of intra-articular adipose tissues in OA and raise important questions for future investigations.

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References

  1. Thijssen, E., van Caam, A. & van der Kraan, P. M. Obesity and osteoarthritis, more than just wear and tear: pivotal roles for inflamed adipose tissue and dyslipidaemia in obesity-induced osteoarthritis. Rheumatology (Oxford) 54, 588–600 (2015).

    Article  CAS  Google Scholar 

  2. Ioan-Facsinay, A. & Kloppenburg, M. An emerging player in knee osteoarthritis: the infrapatellar fat pad. Arthritis Res. Ther. 15, 225 (2013).

    Article  PubMed Central  Google Scholar 

  3. Bastiaansen-Jenniskens, Y. M. et al. Stimulation of fibrotic processes by the infrapatellar fat pad in cultured synoviocytes from patients with osteoarthritis: a possible role for prostaglandin F2α . Arthritis Rheum. 65, 2070–2080 (2013).

    Article  CAS  Google Scholar 

  4. Eymard, F. et al. Induction of an inflammatory and prodegradative phenotype in autologous fibroblast-like synoviocytes by the infrapatellar fat pad from patients with knee osteoarthritis. Arthritis Rheumatol. 66, 2165–2174 (2014).

    Article  CAS  Google Scholar 

  5. Eymard, F. et al. Knee and hip intra-articular adipose tissues (IAATs) compared with autologous subcutaneous adipose tissue: a specific phenotype for a central player in osteoarthritis. Ann. Rheum. Dis. http://dx.doi.org/10.1136/annrheumdis-2016-210478 (2017).

  6. Barboza, E. et al. Pro-fibrotic infrapatellar fat pad remodeling without M1-macrophage polarization precedes knee osteoarthritis in diet-induced obese mice. Arthritis Rheumatol. http://dx.doi.org/10.1002/art.40056 (2017).

  7. Klein-Wieringa, I. R. et al. Inflammatory cells in patients with endstage knee osteoarthritis: a comparison between the synovium and the infrapatellar fat pad. J. Rheumatol. 43, 771–778 (2016).

    Article  Google Scholar 

  8. Sun, K., Kusminski, C. M. & Scherer, P. E. Adipose tissue remodeling and obesity. J. Clin. Invest. 121, 2094–2101 (2011).

    Article  CAS  PubMed Central  Google Scholar 

  9. Chuckpaiwong, B., Charles, H. C., Kraus, V. B., Guilak, F. & Nunley, J. A. Age-associated increases in the size of the infrapatellar fat pad in knee osteoarthritis as measured by 3T MRI. J. Orthop. Res. 28, 1149–1154 (2010).

    Article  PubMed Central  Google Scholar 

  10. Iwata, M. et al. Initial responses of articular tissues in a murine high-fat diet-induced osteoarthritis model: pivotal role of the IPFP as a cytokine fountain. PLoS ONE 8, e60706 (2013).

    Article  CAS  PubMed Central  Google Scholar 

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Acknowledgements

The authors' work is supported by the Dutch Arthritis Foundation (LLP24; A.I.-F., M.K.) and the Innovative Medicine Initiative Joint Undertaking funded project Be The Cure (115142–2; A.I.-F.).

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  1. Department of Rheumatology, Leiden University Medical Center, P. O. Box 9600, Leiden, 2300 RC, Netherlands

    Andreea Ioan-Facsinay & Margreet Kloppenburg

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  1. Andreea Ioan-Facsinay
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  2. Margreet Kloppenburg
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Correspondence to Margreet Kloppenburg.

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The authors declare no competing financial interests.

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Ioan-Facsinay, A., Kloppenburg, M. Inflammation and fibrosis in adipose tissue of osteoarthritic joints. Nat Rev Rheumatol 13, 325–326 (2017). https://doi.org/10.1038/nrrheum.2017.53

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