Figure 2 : Targeted versus untargeted metabolomics approaches.

From: Mixing omics: combining genetics and metabolomics to study rheumatic diseases

Figure 2

Two main approaches exist for carrying out metabolic profiling: targeted and untargeted. The scope of these two types of analysis is different and they both have advantages and disadvantages. Targeted metabolomics approaches have a low detection limit and enable the absolute quantification of the sample. However, targeted methods do not enable the discovery of unknown compounds. Untargeted metabolomics approaches provide a global view of a sample. The disadvantages of untargeted methods include the complex informatics required to interpret the results, the semi-quantitative nature of the methods and the need to validate any identified compounds.