A pioneering new study scrutinising the genetic aetiology of Sjögren syndrome across different ancestries and clinical subtypes shows that the striking heterogeneity of associations observed in Sjögren syndrome cannot be explained by subphenotype differences alone.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
Prices may be subject to local taxes which are calculated during checkout
Shiboski, C. H. et al. 2016 American College of Rheumatology/European League Against Rheumatism classification criteria for primary Sjögren's syndrome: a consensus and data-driven methodology involving three international patient cohorts. Arthritis Rheumatol. 69, 35–45 (2017).
Gøransson, L. G. et al. The point prevalence of clinically relevant primary Sjögren's syndrome in two Norwegian counties. Scand. J. Rheumatol. 40, 221–224 (2011).
Dafni, U. G., Tzioufas, A. G., Staikos, P., Skopouli, F. N. & Moutsopoulos, H. M. Prevalence of Sjögren's syndrome in a closed rural community. Ann. Rheum. Dis. 56, 521–525 (1997).
Zhang, N. Z. et al. Prevalence of primary Sjögren's syndrome in China. J. Rheumatol. 22, 659–661 (1995).
Maldini, C. et al. Epidemiology of primary Sjögren's syndrome in a French multiracial/multiethnic area. Arthritis Care Res. 66, 454–463 (2014).
Taylor, K. E. et al. Genome-wide association analysis reveals genetic heterogeneity of Sjögren's syndrome according to ancestry. Arthritis Rheumatol. http://dx.doi.org/10.1002/art.40040 (2017).
Li, Y. et al. A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23. Nat. Genet. 45, 1361–1365 (2013).
Lessard, C. J. et al. Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. Nat. Genet. 45, 1284–1292 (2013).
Cruz-Tapias, P., Rojas-Villarraga, A., Maier-Moore, S. & Anaya, J.-M. HLA and Sjögren's syndrome susceptibility. A meta-analysis of worldwide studies. Autoimmun. Rev. 11, 281–287 (2012).
Imgenberg-Kreuz, J. et al. Genome-wide DNA methylation analysis in multiple tissues in primary Sjögren's syndrome reveals regulatory effects at interferon-induced genes. Ann. Rheum. Dis. 75, 2029–2036 (2016).
The authors' research is supported by the Research Council of Norway (240421/F20), the EU H2020 contract HarmonicSS (H2020-SC1-2016-RTD/731944) and the Broegelmann Foundation.
The authors declare no competing financial interests.
About this article
Cite this article
Reksten, T., Jonsson, R. Sjögren syndrome genetics vary according to ancestry. Nat Rev Rheumatol 13, 202–203 (2017). https://doi.org/10.1038/nrrheum.2017.36