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Connective tissue diseases

Sjögren syndrome genetics vary according to ancestry

Nature Reviews Rheumatology volume 13, pages 202–203 (2017)Cite this article

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A pioneering new study scrutinising the genetic aetiology of Sjögren syndrome across different ancestries and clinical subtypes shows that the striking heterogeneity of associations observed in Sjögren syndrome cannot be explained by subphenotype differences alone.

Refers to Taylor, K. E. et al. Genome-wide association analysis reveals genetic heterogeneity of Sjögren's syndrome according to ancestry. Arthritis Rheumatol. http://dx.doi.org/10.1002/art.40040 (2017)

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Acknowledgements

The authors' research is supported by the Research Council of Norway (240421/F20), the EU H2020 contract HarmonicSS (H2020-SC1-2016-RTD/731944) and the Broegelmann Foundation.

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Authors and Affiliations

  1. Department of Clinical Science, Tove Ragna Reksten and Roland Jonsson are at the Broegelmann Research Laboratory, University of Bergen, Laboratory Building, Jonas Lies vei 87, Bergen N-5021, Norway,

    Tove Ragna Reksten & Roland Jonsson

  2. Tove Ragna Reksten is also at the Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA.,

    Tove Ragna Reksten

  3. Roland Jonsson is also at the Department of Rheumatology, Haukeland University Hospital, Bergen N-5021, Norway,

    Roland Jonsson

Authors
  1. Tove Ragna Reksten
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  2. Roland Jonsson
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Correspondence to Roland Jonsson.

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The authors declare no competing financial interests.

Supplementary information

Supplementary information S1 (table)

Regions of genetic associations in Sjögren syndrome (PDF 137 kb)

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Reksten, T., Jonsson, R. Sjögren syndrome genetics vary according to ancestry. Nat Rev Rheumatol 13, 202–203 (2017). https://doi.org/10.1038/nrrheum.2017.36

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