Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Bone

Osteoblasts and global energy metabolism – beyond osteocalcin

Nature Reviews Rheumatology volume 13, pages 261–262 (2017)Cite this article

Subjects

There is mounting evidence that osteoblasts are involved in the regulation of global energy metabolism. Although osteocalcin signalling remains important, the complexity of systemic energy storage and expenditure makes it likely that hitherto unknown factors are also involved in osteoblast-mediated regulation of metabolism.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Lee, N. K. et al. Endocrine regulation of energy metabolism by the skeleton. Cell 130, 456–469 (2007).

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Fulzele, K. et al. Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition. Cell 142, 309–319 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Brennan-Speranza, T. C. et al. Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism. J. Clin. Invest. 122, 4172–4189 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Yoshikawa, Y. et al. Genetic evidence points to an osteocalcin-independent influence of osteoblasts on energy metabolism. J. Bone Miner. Res. 26, 2012–2025 (2011).

    Article  CAS  PubMed  Google Scholar 

  5. Yao, Q. et al. Wnt/β-catenin signalling in osteoblasts regulates global energy metabolism. Bone 97, 175–183 (2017).

    Article  CAS  PubMed  Google Scholar 

  6. Kanazawa, I. et al. Serum osteocalcin level is associated with glucose metabolism and atherosclerosis parameters in type 2 diabetes mellitus. J. Clin. Endocrinol. Metab. 94, 45–49 (2009).

    Article  CAS  PubMed  Google Scholar 

  7. Fernandez-Real, J. M. et al. The relationship of serum osteocalcin concentration to insulin secretion, sensitivity, and disposal with hypocaloric diet and resistance training. J. Clin. Endocrinol. Metab. 94, 237–245 (2009).

    Article  CAS  PubMed  Google Scholar 

  8. Ferron, M. & Lacombe, J. Regulation of energy metabolism by the skeleton: osteocalcin and beyond. Arch. Biochem. Biophys. 561, 137–146 (2014).

    Article  CAS  PubMed  Google Scholar 

  9. Frey, J. L. et al. Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast. Mol. Cell. Biol. 35, 1979–1991 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Bone Research Program, ANZAC Research Institute, The University of Sydney, Hospital Road, Sydney, 2139, NSW, Australia

    Hong Zhou & Markus J. Seibel

Authors
  1. Hong Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Markus J. Seibel
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Markus J. Seibel.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhou, H., Seibel, M. Osteoblasts and global energy metabolism – beyond osteocalcin. Nat Rev Rheumatol 13, 261–262 (2017). https://doi.org/10.1038/nrrheum.2017.35

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrrheum.2017.35

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing