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Spondyloarthropathies

Ruminococcus on the horizon in arthritic disease

Nature Reviews Rheumatology volume 13, pages 574–576 (2017)Cite this article

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Increasing evidence points to a mechanistic link between gut and joint pathology as the gut contains the largest number of immune cells of any tissue and trillions of commensals that contribute to immune development and homeostasis. New research is putting the role of Ruminococcus gnavus in arthritic disease in the spotlight.

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Figure 1: Disturbed microbiota–host interactions in spondyloarthritis.

References

  1. Van Praet, L. et al. Microscopic gut inflammation in axial spondyloarthritis: a multiparametric predictive model. Ann. Rheum. Dis. 72, 414–417 (2013).

    Article  Google Scholar 

  2. Diamanti, A. P., Manuela Rosado, M., Lagana, B. & D'Amelio, R. Microbiota and chronic inflammatory arthritis: an interwoven link. J. Transl Med. 14, 233 (2016).

    Article  Google Scholar 

  3. Breban, M. et al. Faecal microbiota study reveals specific dysbiosis in spondyloarthritis. Ann. Rheum. Dis. http://dx.doi.org/10.1136/annrheumdis-2016-211064 (2017).

  4. Abdollahi-Roodsaz, S., Abramson, S. B. & Scher, J. U. The metabolic role of the gut microbiota in health and rheumatic disease: mechanisms and interventions. Nat. Rev. Rheumatol. 12, 446–455 (2016).

    Article  CAS  Google Scholar 

  5. Pianta, A. et al. Two rheumatoid arthritis-specific autoantigens correlate microbial immunity with autoimmune responses in joints. J. Clin. Invest. http://dx.doi.org/10.1172/JCI93450 (2017).

  6. Tito, R. Y. et al. Brief report: Dialister as a microbial marker of disease activity in spondyloarthritis. Arthritis Rheumatol. 69, 114–121 (2017).

    Article  CAS  Google Scholar 

  7. Crost, E. H. et al. The mucin-degradation strategy of Ruminococcus gnavus: the importance of intramolecular trans-sialidases. Gut Microbes 7, 302–312 (2016).

    Article  CAS  Google Scholar 

  8. Everard, A. et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc. Natl Acad. Sci. USA 110, 9066–9071 (2013).

    Article  CAS  Google Scholar 

  9. Stoll, M. L. Gut microbes, immunity, and spondyloarthritis. Clin. Immunol. 159, 134–142 (2015).

    Article  CAS  Google Scholar 

  10. Beaud, D., Tailliez, P. & Anba-Mondoloni, J. Genetic characterization of the β-glucuronidase enzyme from a human intestinal bacterium, Ruminococcus gnavus. Microbiology 151, 2323–2330 (2005).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Rheumatology, Laboratory for Molecular Immunology and Inflammation, University Hospital Ghent, De Pintelaan 185, 0K12B, B-9000 Ghent, Belgium; and at the Vlaams Instituut voor Biotechnologie (VIB) Center for Inflammation Research (IRC), Fiers-Schell-Van Montagu Building, Technologiepark 927, Ghent University, B-9052 Ghent, Belgium.,

    Lars Vereecke & Dirk Elewaut

  2. and at the Vlaams Instituut voor Biotechnologie (VIB) Center for Inflammation Research (IRC), Fiers-Schell-Van Montagu Building, Technologiepark 927, Ghent University, B-9052 Ghent, Belgium.,

    Lars Vereecke & Dirk Elewaut

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  1. Lars Vereecke
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  2. Dirk Elewaut
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Correspondence to Dirk Elewaut.

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The authors declare no competing financial interests.

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Vereecke, L., Elewaut, D. Ruminococcus on the horizon in arthritic disease. Nat Rev Rheumatol 13, 574–576 (2017). https://doi.org/10.1038/nrrheum.2017.130

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