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Osteoarthritis

Time to put steroid injections behind us?

Nature Reviews Rheumatology volume 13, pages 519520 (2017) | Download Citation

Intra-articular corticosteroid injections are a long-established treatment for knee osteoarthritis (OA), but new findings indicate they are not effective, and even potentially harmful. Is it time to rethink the use of this treatment?

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References

  1. 1.

    , , & Hydrocortisone and cortisone injected into arthritic joints: comparative effects of and use of hydrocortisone as a local antiarthritic agent. J. Am. Med. Assoc. 147, 1629–1635 (1951).

  2. 2.

    et al. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res. (Hoboken) 64, 455–474 (2012).

  3. 3.

    et al. Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis. Lancet (2017).

  4. 4.

    et al. Osteoarthritis year in review 2016: imaging. Osteoarthritis Cartilage 25, 216–226 (2017).

  5. 5.

    , & Use of saline as a placebo in intra-articular injections in osteoarthritis: potential contributions to nociceptive pain relief. Open Rheumatol. J. 11, 16–22 (2017).

  6. 6.

    et al. Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis. Ann. Intern. Med. 162, 46–54 (2015).

  7. 7.

    et al. Intraarticular injections with methylprednisolone acetate reduce osteoarthritic lesions in parallel with chondrocyte stromelysin synthesis in experimental osteoarthritis. Arthritis Rheum. 37, 414–423 (1994).

  8. 8.

    et al. Intra-articular corticosteroid for knee osteoarthritis. Cochrane Database Syst. Rev. 10, CD005328 (2015).

  9. 9.

    et al. Evaluation of the benefit of corticosteroid injection before exercise therapy in patients with osteoarthritis of the knee: a randomized clinical trial. JAMA Intern. Med. 175, 923–930 (2015).

  10. 10.

    et al. Safety and efficacy of long-term intraarticular steroid injections in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 48, 370–377 (2003).

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Author information

Affiliations

  1. Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark.

    • Henning Bliddal
  2. Parker Institute and the department of physical and occupational therapy, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark.

    • Marius Henriksen

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Henning Bliddal.

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DOI

https://doi.org/10.1038/nrrheum.2017.118

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