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Osteoarthritis

Time to put steroid injections behind us?

Nature Reviews Rheumatology volume 13, pages 519–520 (2017)Cite this article

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Intra-articular corticosteroid injections are a long-established treatment for knee osteoarthritis (OA), but new findings indicate they are not effective, and even potentially harmful. Is it time to rethink the use of this treatment?

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References

  1. Hollander, J. L., Brown, E. M. Jr., Jessar, R. A. & Brown, C. Y. Hydrocortisone and cortisone injected into arthritic joints: comparative effects of and use of hydrocortisone as a local antiarthritic agent. J. Am. Med. Assoc. 147, 1629–1635 (1951).

    Article  CAS  Google Scholar 

  2. Hochberg, M. C. et al. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res. (Hoboken) 64, 455–474 (2012).

    Article  Google Scholar 

  3. da Costa, B. R. et al. Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis. Lancet https://doi.org/10.1016/S0140-6736(17)31744-0 (2017).

    Article  CAS  Google Scholar 

  4. Boesen, M. et al. Osteoarthritis year in review 2016: imaging. Osteoarthritis Cartilage 25, 216–226 (2017).

    Article  CAS  Google Scholar 

  5. Bar-Or, D., Rael, L. T. & Brody, E. N. Use of saline as a placebo in intra-articular injections in osteoarthritis: potential contributions to nociceptive pain relief. Open Rheumatol. J. 11, 16–22 (2017).

    Article  CAS  Google Scholar 

  6. Bannuru, R. R. et al. Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis. Ann. Intern. Med. 162, 46–54 (2015).

    Article  Google Scholar 

  7. Pelletier, J. P. et al. Intraarticular injections with methylprednisolone acetate reduce osteoarthritic lesions in parallel with chondrocyte stromelysin synthesis in experimental osteoarthritis. Arthritis Rheum. 37, 414–423 (1994).

    Article  CAS  Google Scholar 

  8. Juni, P. et al. Intra-articular corticosteroid for knee osteoarthritis. Cochrane Database Syst. Rev. 10, CD005328 (2015).

    Google Scholar 

  9. Henriksen, M. et al. Evaluation of the benefit of corticosteroid injection before exercise therapy in patients with osteoarthritis of the knee: a randomized clinical trial. JAMA Intern. Med. 175, 923–930 (2015).

    Article  Google Scholar 

  10. Raynauld, J. P. et al. Safety and efficacy of long-term intraarticular steroid injections in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 48, 370–377 (2003).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark

    Henning Bliddal

  2. Parker Institute and the department of physical and occupational therapy, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark

    Marius Henriksen

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  1. Henning Bliddal
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  2. Marius Henriksen
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Correspondence to Henning Bliddal.

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The authors declare no competing financial interests.

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Bliddal, H., Henriksen, M. Time to put steroid injections behind us?. Nat Rev Rheumatol 13, 519–520 (2017). https://doi.org/10.1038/nrrheum.2017.118

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