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Regenerative medicine

Breaking Prometheus's curse for cartilage regeneration

Nature Reviews Rheumatology volume 13, pages 516–518 (2017)Cite this article

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Like the mythical eagle devouring Prometheus's liver as fast as it regrew, chronic inflammation hinders cartilage regeneration in inflammatory arthritis. Using stem cells engineered to secrete anti-inflammatory molecules in response to local inflammatory factors could provide a way to keep the eagle at bay as the stem cells differentiate into chondrocytes.

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Figure 1: CRISPR–Cas9-based reprogramming of chondrogenic stem cells to combat inflammation.

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Acknowledgements

The author's research is supported by INSERM, the University and hospital of Montpellier, the EU Innovative Medicines Initiative-funded project BeTheCure (#115142) and the Arthritis Foundation Courtin.

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Authors and Affiliations

  1. France; and at the Clinical Department for Osteoarticular Diseases, Florence Apparailly is at Inserm U1183, Institut de Médecine Régénérative et Biothérapies, Centre Hospitalier Universitaire (CHU) Saint Eloi, 80 Rue Augustin Fliche, 34295 Montpellier Cedex 5, CHU Lapeyronie, Avenue Gaston Giraud, 34295 Montpellier, France.,

    Florence Apparailly

  2. and at the Clinical Department for Osteoarticular Diseases, CHU Lapeyronie, Avenue Gaston Giraud, 34295 Montpellier, France.,

    Florence Apparailly

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  1. Florence Apparailly
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Correspondence to Florence Apparailly.

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Apparailly, F. Breaking Prometheus's curse for cartilage regeneration. Nat Rev Rheumatol 13, 516–518 (2017). https://doi.org/10.1038/nrrheum.2017.116

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