Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Year in Review
  • Published:

Myositis in 2016

New tools for diagnosis and therapy

In 2016, there have been several major scientific achievements related to myositis, including the discovery of a novel autoantibody and the relationship between autoantibodies and distinct clinical phenotypes. Advances in the way clinical trials are conducted have also led to breakthroughs in treatment strategies.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Myositis-specific autoantibodies in adult and juvenile myositis.

References

  1. Hozumi, H. et al. Comprehensive assessment of myositis-specific autoantibodies in polymyositis/dermatomyositis-associated interstitial lung disease. Respir. Med. 121, 91–99 (2016).

    Article  Google Scholar 

  2. Pinal-Fernandez, I. et al. Longitudinal course of disease in a large cohort of myositis patients with autoantibodies recognizing the signal recognition particle. Arthritis Care Res. (Hoboken) http://dx.doi.org/10.1002/acr.22920 (2016).

  3. Pinal-Fernandez, I. et al. Thigh muscle MRI in immune-mediated necrotising myopathy: extensive oedema, early muscle damage and role of anti-SRP autoantibodies as a marker of severity. Ann. Rheum. Dis. http://dx.doi.org/10.1136/annrheumdis-2016-210198 (2016).

  4. Mescam-Mancini, L. et al. Anti-Jo-1 antibody-positive patients show a characteristic necrotizing perifascicular myositis. Brain 138, 2485–2492 (2015).

    Article  Google Scholar 

  5. Pinal-Fernandez, I., Casciola-Rosen, L. A., Christopher-Stine, L., Corse, A. M. & Mammen, A. L. The prevalence of individual histopathologic features varies according to autoantibody status in muscle biopsies from patients with dermatomyositis. J. Rheumatol. 42, 1448–1454 (2015).

    Article  CAS  Google Scholar 

  6. Albrecht, I. et al. Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies. J. Clin. Invest. 125, 4612–4624 (2015).

    Article  Google Scholar 

  7. Ruperto, N. et al. Prednisone versus prednisone plus ciclosporin versus prednisone plus methotrexate in new-onset juvenile dermatomyositis: a randomised trial. Lancet 387, 671–678 (2016).

    Article  Google Scholar 

  8. Munters, L. A. et al. Endurance exercise improves molecular pathways of aerobic metabolism in patients with myositis. Arthritis Rheumatol. 68, 1738–1750 (2016).

    Article  CAS  Google Scholar 

  9. Euromyositis Network. The International Euromyositis Register www.euromyositis.eu (2016).

Download references

Acknowledgements

I.L. would like to thank H. Gunawardena of North Bristol NHS Trust, UK, for sharing information on clinical features in relation to myositis-specific autoantibodies. I.L. receives support from the Swedish Research Council (grant number K2014-52X-14045-14-3) and the Regional Agreement on Medical Training and Clinical Research (ALF) between Stockholm County Council and the Karolinska Institutet.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ingrid E. Lundberg.

Ethics declarations

Competing interests

The author declares that she has received research grants from Astra Zeneca and Bristol-Myers Squibb, and has served on the advisory board for Bristol-Myers Squibb and Idera Pharmaceuticals.

PowerPoint slides

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lundberg, I. New tools for diagnosis and therapy. Nat Rev Rheumatol 13, 74–76 (2017). https://doi.org/10.1038/nrrheum.2017.1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrrheum.2017.1

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing