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Connective tissue diseases

Nucleosomes and systemic sclerosis

Systemic sclerosis (SSc) is characterized by an abnormal immune response to innocuous antigens that might lead to autoantibody production. New observations suggest that nucleosomes can mediate both IgG production and B-cell proliferation, via Toll-like receptor signalling, and thereby affect the pathogenesis of SSc.

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Correspondence to Steven O'Reilly or Jacob M. van Laar.

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The authors declare no competing financial interests.

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O'Reilly, S., van Laar, J. Nucleosomes and systemic sclerosis. Nat Rev Rheumatol 12, 138–139 (2016).

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