Systemic sclerosis (SSc) is characterized by an abnormal immune response to innocuous antigens that might lead to autoantibody production. New observations suggest that nucleosomes can mediate both IgG production and B-cell proliferation, via Toll-like receptor signalling, and thereby affect the pathogenesis of SSc.
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The authors declare no competing financial interests.
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O'Reilly, S., van Laar, J. Nucleosomes and systemic sclerosis. Nat Rev Rheumatol 12, 138–139 (2016). https://doi.org/10.1038/nrrheum.2016.9
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