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Connective tissue diseases

Nucleosomes and systemic sclerosis

Nature Reviews Rheumatology volume 12, pages 138–139 (2016)Cite this article

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Systemic sclerosis (SSc) is characterized by an abnormal immune response to innocuous antigens that might lead to autoantibody production. New observations suggest that nucleosomes can mediate both IgG production and B-cell proliferation, via Toll-like receptor signalling, and thereby affect the pathogenesis of SSc.

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Authors and Affiliations

  1. Northumbria University, Faculty of Health and Life Sciences, Ellison Building, NE3 3HY, Newcastle upon Tyne, UK

    Steven O'Reilly

  2. Department of Rheumatology and Immunology, University Medical Centre (UMC) Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, Netherlands

    Jacob M. van Laar

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  1. Steven O'Reilly
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  2. Jacob M. van Laar
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Correspondence to Steven O'Reilly or Jacob M. van Laar.

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The authors declare no competing financial interests.

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O'Reilly, S., van Laar, J. Nucleosomes and systemic sclerosis. Nat Rev Rheumatol 12, 138–139 (2016). https://doi.org/10.1038/nrrheum.2016.9

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