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Osteoarthritis

Yet another death knell for paracetamol in OA

Nature Reviews Rheumatology volume 12, pages 320–321 (2016)Cite this article

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Although paracetamol is widely used and recommended for the management of pain in osteoarthritis, accumulating data indicate that it lacks efficacy and is associated with severe adverse effects. A new meta-analysis adds further weight to calls for clinical practice and treatment guidelines to be updated to reflect the evidence.

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Acknowledgements

D.J.H. is supported by a National Health and Medical Research Council (NHMRC) Practitioner Fellowship. M.L.F. is supported by Sydney Medical Foundation and Sydney Medical School.

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Authors and Affiliations

  1. and the Rheumatology Department, Institute of Bone and Joint Research, The Kolling Institute, The University of Sydney at Royal North Shore Hospital, Royal North Shore Hospital, St Leonards, Sydney, 2065, NSW, Australia

    David J. Hunter

  2. Institute of Bone and Joint Research, The Kolling Institute, The University of Sydney at Royal North Shore Hospital, St Leonards, Sydney, 2065, NSW

    Manuela L. Ferreira

  3. The George Institute for Global Health, PO Box M201, Missenden Rd

    Manuela L. Ferreira

  4. Sydney Medical School, The University of Sydney, Sydney, 2050, NSW, Australia

    Manuela L. Ferreira

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  1. David J. Hunter
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Contributions

D.J.H. researched data for the article. Both authors contributed to discussion of the content, writing the article, and reviewing and editing the manuscript before submission.

Corresponding author

Correspondence to David J. Hunter.

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Competing interests

D.J.H. declares that he is a consultant to Flexion, Nestle and Merck Serono. M.L.F. declares no competing interests.

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Hunter, D., Ferreira, M. Yet another death knell for paracetamol in OA. Nat Rev Rheumatol 12, 320–321 (2016). https://doi.org/10.1038/nrrheum.2016.79

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