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Osteoarthritis

Bone as an imaging biomarker and treatment target in OA

Nature Reviews Rheumatology volume 12, pages 503–504 (2016)Cite this article

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Radiographic joint-space width is the standard structural outcome for trials in knee osteoarthritis (OA), but MRI provides comprehensive 3D insights into the multi-tissue pathology of OA and could provide a superior means of monitoring disease progression and response to treatment. A new study highlights bone as an imaging biomarker.

Refers to Barr, A. J. et al. The relationship between three-dimensional knee MRI bone shape and total knee replacement — a case–control study: data from the Osteoarthritis Initiative. Rheumatology (Oxford) http://dx.doi.org/10.1093/rheumatology/kew191 (2016)

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Figure 1: 3D femur bone shape changes in osteoarthritis.

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Acknowledgements

This work was supported by NIH grant AR47785 (to T.N. and D.T.F.) and an Arthritis Foundation Innovative Research Grant (to T.N.).

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  1. Boston University School of Medicine, 650 Albany Street, Clin Epi Unit, Suite X200, Boston, 02118, Massachusetts, USA

    Tuhina Neogi & David T. Felson

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  1. Tuhina Neogi
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Correspondence to Tuhina Neogi.

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The authors declare no competing financial interests.

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Neogi, T., Felson, D. Bone as an imaging biomarker and treatment target in OA. Nat Rev Rheumatol 12, 503–504 (2016). https://doi.org/10.1038/nrrheum.2016.113

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