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Bone as an imaging biomarker and treatment target in OA

Radiographic joint-space width is the standard structural outcome for trials in knee osteoarthritis (OA), but MRI provides comprehensive 3D insights into the multi-tissue pathology of OA and could provide a superior means of monitoring disease progression and response to treatment. A new study highlights bone as an imaging biomarker.

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Figure 1: 3D femur bone shape changes in osteoarthritis.


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This work was supported by NIH grant AR47785 (to T.N. and D.T.F.) and an Arthritis Foundation Innovative Research Grant (to T.N.).

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Correspondence to Tuhina Neogi.

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The authors declare no competing financial interests.

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Neogi, T., Felson, D. Bone as an imaging biomarker and treatment target in OA. Nat Rev Rheumatol 12, 503–504 (2016).

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