Given the established role of 90 kDa ribosomal S6 kinases (Rsk) in oncogenesis, and the promise of new Rsk-blocking cancer treatments, it is perhaps surprising that Rsk2-mediated inhibition of hyperplasia has now been demonstrated to occur in the arthritic synovium. Does this functional duality make Rsk2 a risky target for the treatment of rheumatoid arthritis?
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Falconer, J., Buckley, C. The two faces of Rsk2 in hyperplastic disease. Nat Rev Rheumatol 11, 203–205 (2015). https://doi.org/10.1038/nrrheum.2015.1
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DOI: https://doi.org/10.1038/nrrheum.2015.1
