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Mapping autoimmune disease epigenetics: what's on the horizon?

Nature Reviews Rheumatology volume 11, pages 131–132 (2015)Cite this article

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Can a patient's genotype provide insight into the mechanistic basis of autoimmune disease? A study integrating epigenetic data with finely mapped disease-associated variants sheds light on how noncoding variants might alter gene expression within specific immune cells, and hints at new possibilities for individualizing treatment of autoimmune rheumatic disorders.

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Acknowledgements

C.C.B. is supported by a Wellcome Trust Clinical Research Training Fellowship. L.R.W. is supported by Great Ormond Street Children's Charity. The Centre for Adolescent Rheumatology (L.R.W.) is supported by Arthritis Research UK, UCLH Biomedical Research Centre and Great Ormond Street Children's Charity.

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Authors and Affiliations

  1. Division of Transplantation Immunology and Mucosal Biology, King's College London, London, SE1 9RT, UK

    Chrysothemis C. Brown

  2. Infection, Immunity, Inflammation and Physiological Medicine Programme, UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK

    Lucy R. Wedderburn

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  1. Chrysothemis C. Brown
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  2. Lucy R. Wedderburn
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Correspondence to Lucy R. Wedderburn.

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The authors declare no competing financial interests.

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Brown, C., Wedderburn, L. Mapping autoimmune disease epigenetics: what's on the horizon?. Nat Rev Rheumatol 11, 131–132 (2015). https://doi.org/10.1038/nrrheum.2014.210

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