Pain is modulated by a variety of contextual factors
Positive contexts, such as those related to placebo administration, have been found to activate a number of endogenous antinociceptive systems
Negative contexts, such as those related to nocebo effects, activate endogenous systems that increase pain
Contexts with positive meanings might even turn pain into a rewarding experience
If therapy has no positive context, so that patients have no expectations of benefit, the effectiveness of treatment is reduced
Consultations, diagnostic procedures and treatments are carried out within a context; this context might be a crucial determinant of symptom perception and therapeutic outcome
Pain is a sensory and emotional experience that is substantially modulated by psychological, social and contextual factors. Research now indicates that the influence of these factors is even more powerful than expected and involves the therapeutic response to analgesic drugs as well as the pain experience itself, which in some circumstances can even be a form of reward. Different experimental approaches and models, both in the laboratory and in the clinical setting, have been used to better characterize and understand the complex neurobiology of pain modulation. These approaches include placebo analgesia, nocebo hyperalgesia, hidden administration of analgesics, and the manipulation of the pain–reward relationship. Overall, these studies show that different neurochemical systems are activated in different positive and negative contexts. Moreover, pain can activate reward mechanisms when experienced within contexts that have special positive meaning. Because routine medical practice usually takes place in contexts that use different rituals, these neurobiological insights might have profound clinical implications.
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This work was supported by Compagnia di San Paolo, Carlo Molo Foundation, and Volkswagen Foundation.
The authors declare no competing financial interests.
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Carlino, E., Frisaldi, E. & Benedetti, F. Pain and the context. Nat Rev Rheumatol 10, 348–355 (2014). https://doi.org/10.1038/nrrheum.2014.17
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