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Therapy

Bisphosphonates for early complex regional pain syndrome

Neridronate, an aminobisphosphonate, has shown promise in reducing the often extreme and intransigent pain of complex regional pain syndrome. Welcomed clinically, what can this finding tell us about the enigmatic mechanisms of bisphosphonates and of complex regional pain syndrome alike?

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Figure 1: Clinical signs of CRPS.

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Littlejohn, G. Bisphosphonates for early complex regional pain syndrome. Nat Rev Rheumatol 9, 199–200 (2013). https://doi.org/10.1038/nrrheum.2013.6

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