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Omega-3 fatty acids and synovitis in osteoarthritic knees

Recently reported associations between synovitis, cartilage damage and plasma levels of omega-3 and omega-6 fatty acids in patients with osteoarthritis suggest that fish oil supplements might be beneficial additions to the therapeutic regime in this disease; however, questions remain regarding the details of this approach, and controlled trials are required.

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Figure 1: Potential protective actions of omega-3 fats in OA.


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Correspondence to Leslie G. Cleland.

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Competing interests

L. G. Cleland and M. J. James have received grant/research support (including clinical trials) from Melrose Laboratories.

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Cleland, L., James, M. Omega-3 fatty acids and synovitis in osteoarthritic knees. Nat Rev Rheumatol 8, 314–315 (2012).

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