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Spondyloarthritis in 2012

Advances in pathogenesis through animal models and imaging

Nature Reviews Rheumatology volume 9, pages 72–74 (2013)Cite this article

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Advances in 2012 have helped to solve several established mysteries in spondyloarthritis (SpA)—why T-cell-directed therapies have not delivered the expected efficacy and how the IL-23–IL-17 cytokine axis is linked to the specific pathology of SpA. The opportunity to influence disease progression at inflammatory lesions using anti-TNF agents may be fleeting.

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Figure 1: Lesion formation in SpA.

References

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  1. Division of Rheumatology, Department of Medicine, 562 HMRB, University of Alberta, Edmonton, T6G 2S2, Alberta, Canada

    Walter P. Maksymowych

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  1. Walter P. Maksymowych
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The author declares that he has received honoraria and grants from Abbott, Amgen, Eli-Lilly, Janssen, Merck, Pfizer and UCB.

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Maksymowych, W. Advances in pathogenesis through animal models and imaging. Nat Rev Rheumatol 9, 72–74 (2013). https://doi.org/10.1038/nrrheum.2012.233

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