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Bone research in 2012

The ups and downs of bone in health and rheumatic disease

Nature Reviews Rheumatology volume 9, pages 67–68 (2013)Cite this article

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In 2012, several new concepts emerged that widen our view of the regulation of bone mass in health and disease. Three key studies outline these discoveries, which affect our understanding of the skeletal system, particularly its physiological function and the changes it undergoes during inflammatory disease.

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Figure 1: Osteoimmune crosstalk regulates osteoblast and osteoclast differentiation and activity.

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Acknowledgements

The work of Georg Schett is supported by the Deutsche Forschungsgemeinschaft (SPP1468-IMMUNOBONE). Ulrike Harre is a member of Graduiertenkolleg 1660, supported by the Deutsche Forschungsgemeinschaft.

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  1. Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, 91054, Germany

    Ulrike Harre & Georg Schett

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  1. Ulrike Harre
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  2. Georg Schett
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Correspondence to Georg Schett.

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The authors declare no competing financial interests.

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Cite this article

Harre, U., Schett, G. The ups and downs of bone in health and rheumatic disease. Nat Rev Rheumatol 9, 67–68 (2013). https://doi.org/10.1038/nrrheum.2012.219

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