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NSAID use early in pregnancy does not increase risk of congenital malformations

Of 110,783 pregnancies during 1998–2009 in southern Israel, 5,267 mothers were exposed to NSAIDs (nonselective cyclooxygenase [COX] and selective COX2 inhibitors) during their first trimester. Intrauterine exposure to NSAIDs did not increase the risk of major congenital malformations in general; however, exposure to selective COX2 inhibitors was associated with an increased risk of musculoskeletal malformations (adjusted OR 3.39; 95% CI 1.37–8.34).


  1. Daniel, S. et al. Major malformations following exposure to nonsteroidal antiinflammatory drugs during the first trimester of pregnancy. J. Rheumatol. doi:10.3899/jrheum.120453

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NSAID use early in pregnancy does not increase risk of congenital malformations. Nat Rev Rheumatol 8, 633 (2012).

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